TMEM243 and CD33

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM243	CD33
Description		transmembrane protein 243	CD33 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Peroxisome Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Specific Granule Membrane Tertiary Granule Membrane
	Molecular Function	Protein Binding	Protein Binding Protein Tyrosine Phosphatase Activator Activity Protein Phosphatase Binding Carbohydrate Binding Sialic Acid Binding Signaling Receptor Activity
	Biological Process		Immune Response-inhibiting Signal Transduction Cell Adhesion Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Fc-gamma Receptor Signaling Pathway Positive Regulation Of Protein Secretion Cell-cell Adhesion Negative Regulation Of Monocyte Activation
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation
Drugs			Gemtuzumab ozogamicin AVE9633
Diseases
GWAS		Lung cancer in never smokers ( 28604730) Schizophrenia ( 29483656)	Alzheimer's disease ( 18976728 31473137) Alzheimer's disease (late onset) ( 21460841 24162737 28714976 30617256) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Basophil count ( 32888494) Blood protein levels ( 30072576) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Eosinophil count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) HIV-1 susceptibility ( 25786224) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triacylglyceride levels ( 31551469) White blood cell count ( 27863252 32888494)
Interacting Genes		46 interacting genes: AQP6 BIK CD33 CD74 CD79A CISD2 CLEC14A CPLX4 CREB3 EBP ELOVL4 ELOVL5 ERGIC3 FAM174A FAM209A FFAR2 GJA8 GPR108 GPR152 GPR37L1 GPX8 HSD17B13 JAGN1 KIR2DL3 LIME1 LMNA LRP10 MRM1 MTIF3 MUC1 PLP1 PSCA RETREG3 RMDN3 SAR1A SCN3B SEC11C SLC10A6 SSMEM1 TMEM101 TMEM14B TMEM35A TMEM45B TMEM80 TMPRSS2 ZFYVE27	21 interacting genes: BMP10 C3orf52 CXCL9 CYB5B EMD GIMAP5 HERC3 KRT31 KRT35 KRT40 PTPN11 PTPN6 RPRM SCD SRC THSD7A TMBIM1 TMEM100 TMEM243 TNMD UBIAD1
Entrez ID		79161	945
HPRD ID		12911	01165
Ensembl ID		ENSG00000135185	ENSG00000105383
Uniprot IDs		C9JY04 Q9BU79	P20138 Q546G0
PDB IDs			5IHB 5J06 5J0B 6D48 6D49 6D4A 6TL8 7AW6
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum B Cell Receptor Complex Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Acetylcholine Receptor Regulator Activity Protein Binding Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Elongation, Saturated Fatty Acid Negative Regulation Of Peptide Secretion Fatty Acid Biosynthetic Process Very Long-chain Fatty Acid Biosynthetic Process Endoplasmic Reticulum Organization Fatty Acid Elongation	Negative Regulation Of Neutrophil Activation Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Neutrophil Activation T Cell Costimulation Structural Constituent Of Skin Epidermis Myeloid Cell Development Intermediate Filament Organization Non-membrane Spanning Protein Tyrosine Phosphatase Activity Tissue Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Cell Differentiation Supramolecular Fiber Organization Peptidyl-tyrosine Dephosphorylation Cellular Developmental Process Cellular Response To Growth Factor Stimulus Platelet Formation Megakaryocyte Development Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Myeloid Leukocyte Activation Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Growth Factor Morphogenesis Of An Epithelium Regulation Of Protein Export From Nucleus TMEM240-body Intermediate Filament Cytoskeleton Organization Cell Activation Involved In Immune Response Leukocyte Activation Involved In Immune Response SH2 Domain Binding Epididymis Development Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Monounsaturated Fatty Acid Biosynthetic Process Vitamin K Biosynthetic Process Menaquinone Biosynthetic Process Epithelial Cell Differentiation Structural Molecule Activity Regulation Of Type I Interferon-mediated Signaling Pathway Hemopoiesis Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Anatomical Structure Morphogenesis Cytokine-mediated Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
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