PLEKHF1 and TNFAIP8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLEKHF1	TNFAIP8
Description		pleckstrin homology and FYVE domain containing 1	TNF alpha induced protein 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Endosome Membrane Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Metal Ion Binding Phosphatidylinositol-4-phosphate Binding	Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Apoptotic Process Endosome Organization Endosome To Lysosome Transport Positive Regulation Of Autophagy Vesicle Organization Protein Localization To Plasma Membrane	Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process
Pathways			PI Metabolism
Drugs
Diseases
GWAS		Body mass index ( 26426971)	A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Apolipoprotein A1 levels ( 32203549) Asthma ( 32296059 31959851 31619474 31361310) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) HDL cholesterol levels in HIV infection ( 33109212) Heschl's gyrus morphology ( 25130324) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Plantar fascial disorders ( 29534260) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Triglyceride levels ( 32154731 32203549) Triglycerides ( 30275531) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971 28552196) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: CAVIN2 CHIC2 KIFBP L3MBTL3 NPM2 TNFAIP8 TNNT1	11 interacting genes: ATN1 EAF1 EAPP INO80E MED4 PLEKHF1 PLEKHF2 PRR13 SDCBP TIFA TMEM132D
Entrez ID		79156	25816
HPRD ID		15146	18204
Ensembl ID		ENSG00000166289	ENSG00000145779
Uniprot IDs		B4DWN9 Q96S99	B3KUI2 O95379
PDB IDs
Enriched GO Terms of Interacting Partners?		Slow-twitch Skeletal Muscle Fiber Contraction Troponin T Binding Oocyte Differentiation Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Methylation-dependent Protein Binding	Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation
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