DEK and DTNBP1

Data Source: HiPPIP (Novel)

		DEK	DTNBP1
Name		DEK proto-oncogene	dystrobrevin binding protein 1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Contractile Muscle Fiber B-WICH Complex	Nucleus Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endosome Membrane Postsynaptic Density Microtubule Cytoskeleton Membrane Sarcoplasm Axon Growth Cone Midbody Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane BLOC-1 Complex Cytoplasmic Vesicle Asymmetric Synapse Melanosome Membrane Sarcolemma Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Axon Cytoplasm
	Molecular Function	DNA Binding RNA Binding Protein Binding Histone Binding	Protein Binding
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Signal Transduction Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Regulation Of Double-strand Break Repair Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Kidney Development Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Receptor Internalization Blood Coagulation Memory Anterograde Axonal Transport Regulation Of Signal Transduction Positive Regulation Of Gene Expression Regulation Of Dopamine Secretion Actin Cytoskeleton Organization Neuron Projection Development Melanosome Organization Anterograde Synaptic Vesicle Transport Neuron Projection Morphogenesis Dendrite Morphogenesis Retina Development In Camera-type Eye Platelet Dense Granule Organization Regulation Of Dopamine Receptor Signaling Pathway Cilium Assembly Negative Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Protein Transmembrane Transport Regulation Of Synaptic Vesicle Exocytosis
Pathways		B-WICH complex positively regulates rRNA expression Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis	Golgi Associated Vesicle Biogenesis
Diseases		None	Hermansky-Pudlak syndrome (HPS)
GWAS		Atrial fibrillation ( 30061737 ) Metabolite levels ( 23823483 ) PR interval ( 32439900 )	Asthma exacerbations in inhaled corticosteroid treatment ( 30697902 ) Corneal astigmatism ( 30306274 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Multiple myeloma ( 27363682 ) Serum alkaline phosphatase levels ( 33547301 ) Squamous cell carcinoma ( 31174203 )
Interacting Genes		16 interacting genes: AP2A1 CDC42 CEBPA CREBBP CSNK2A1 EP300 GPATCH11 H3-4 HLA-A KAT2B OGT SRRM1 TFAP2A TRIM55 TRIM63 ZIK1	51 interacting genes: ABI3 AKAP6 ARFIP2 BICRAL BLOC1S5 BLOC1S6 BRF1 CCDC146 CCNA2 CCND3 CMYA5 DCTN1 DGCR6L DRC12 DST DTNA DTNB ELOVL7 HAUS1 IFT20 IPO5 KALRN KANSL1 KIAA0408 KIFC3 KRT75 MACF1 NBEA NDN NECAB2 NUF2 OIP5 P4HA3 PSME3 RAB11A RBSN SDCBP SFR1 SHFL SNAPIN SRGAP3 SSC5D SYNE1 TNKS TRAF3IP1 TRIM2 TRIM27 TRIM9 VRK2 WASHC3 ZNF490
Entrez ID		7913	84062
HPRD ID		00503	06190
Ensembl ID		ENSG00000124795	ENSG00000047579
Uniprot IDs		H0Y8X0 P35659	A0A087WYP9 A0A0S2Z5U8 A6NFV8 D6RJC6 Q96EV8
PDB IDs		1Q1V 2JX3 8KCY 8KD1	Not available
GO Terms Enriched among Interactors		N-terminal Peptidyl-lysine Acetylation Histone Acetyltransferase Complex Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation Regulation Of Glycolytic Process Regulation Of Carbohydrate Catabolic Process Acetyltransferase Activity Histone H3K27 Acetyltransferase Activity Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Chromatin DNA Binding Protein-lysine-acetyltransferase Activity Histone H3K18 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Histone Acetyltransferase Activity Protein Acetylation Rhythmic Process Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein Maturation L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Gluconeogenesis Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Canonical NF-kappaB Signal Transduction DNA-binding Transcription Factor Binding Regulation Of Transcription By Glucose Internal Protein Amino Acid Acetylation STAT Family Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Chromatin Binding Regulation Of Cellular Response To Heat Response To Nutrient Levels Cellular Response To Nutrient Levels Positive Regulation Of Gene Expression Regulation Of Glucose Metabolic Process Learning Or Memory Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Negative Regulation Of Small Molecule Metabolic Process Sin3-type Complex Regulation Of Attachment Of Spindle Microtubules To Kinetochore Memory Cognition Transcription Coregulator Activity Negative Regulation Of Transcription By RNA Polymerase II	Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Pigment Granule Localization Axonal Transport Microtubule-based Movement Transport Along Microtubule BLOC-1 Complex Anterograde Synaptic Vesicle Transport Axo-dendritic Transport Cytoskeleton-dependent Intracellular Transport Microtubule-based Process Microtubule-based Transport Establishment Of Vesicle Localization Axon Cytoplasm Microvesicle Vesicle Localization Endosome To Melanosome Transport Plasma Membrane Bounded Cell Projection Organization Synaptic Vesicle Transport Intracellular Transport Melanosome Organization Cellular Localization Nuclear Envelope Pigment Granule Organization Cell Projection Organization Anterograde Axonal Transport Organelle Organization Vesicle Transport Along Microtubule Cytoskeleton Organization Cytoplasm Microtubule Binding Nuclear Membrane Vesicle Cytoskeletal Trafficking Centrosome Establishment Of Protein Localization Cytoskeleton Secretion Of Lysosomal Enzymes Protein Transmembrane Transport Regulation Of Organelle Organization Establishment Of Localization In Cell Positive Regulation Of Pigment Cell Differentiation Spindle Pole Plasma Membrane Bounded Cell Projection Assembly Neuron Projection Development Organelle Transport Along Microtubule Regulation Of Actin Nucleation Cell Projection Assembly Protein Transport