DTNBP1 and TPMT

		DTNBP1	TPMT
Description		dystrobrevin binding protein 1	thiopurine S-methyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endosome Membrane Postsynaptic Density Microtubule Cytoskeleton Membrane Sarcoplasm Axon Growth Cone Midbody Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane BLOC-1 Complex Cytoplasmic Vesicle Asymmetric Synapse Melanosome Membrane Sarcolemma Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Axon Cytoplasm	Cytoplasm Cytosol
	Molecular Function	Protein Binding	Protein Binding Thiopurine S-methyltransferase Activity Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity S-adenosyl-L-methionine Binding
	Biological Process	Kidney Development Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Receptor Internalization Blood Coagulation Memory Anterograde Axonal Transport Regulation Of Signal Transduction Positive Regulation Of Gene Expression Regulation Of Dopamine Secretion Actin Cytoskeleton Organization Neuron Projection Development Melanosome Organization Anterograde Synaptic Vesicle Transport Neuron Projection Morphogenesis Dendrite Morphogenesis Retina Development In Camera-type Eye Platelet Dense Granule Organization Regulation Of Dopamine Receptor Signaling Pathway Cilium Assembly Negative Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Protein Transmembrane Transport Regulation Of Synaptic Vesicle Exocytosis	Nucleobase-containing Compound Metabolic Process Xenobiotic Metabolic Process Methylation Xenobiotic Catabolic Process
Pathways		Golgi Associated Vesicle Biogenesis	Methylation Defective TPMT causes TPMT deficiency Azathioprine ADME
Drugs			Olsalazine
Diseases		Hermansky-Pudlak syndrome (HPS)	Thiopurine S-methyltransferase deficiency (TPMT deficiency)
GWAS		Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Corneal astigmatism ( 30306274) Femur bone mineral density x serum urate levels interaction ( 34046847) Liver enzyme levels (alkaline phosphatase) ( 33972514) Multiple myeloma ( 27363682) Serum alkaline phosphatase levels ( 33547301) Squamous cell carcinoma ( 31174203)	DNA-incorporated thioguanine levels in 6-mercaptopurine-treated acute lymphoblastic leukaemia ( 30201983) Erythrocyte methylated 6-mercaptopurine metabolite concentration in 6-mercaptopurine-treated acute lymphoblastic leukaemia ( 30201983) Erythrocyte thioguanine concentration in 6-mercaptopurine-treated acute lymphoblastic leukaemia ( 30201983) Thiopurine methyltransferase activity in acute lymphoblastic leukemia patients treated with mercaptopurines ( 27564568) Thiopurine S-methyltransferase activity ( 27770449) Thiopurine-induced myelosuppression in inflammatory bowel disease ( 30806694)
Interacting Genes		51 interacting genes: ABI3 AKAP6 ARFIP2 BICRAL BLOC1S5 BLOC1S6 BRF1 CCDC146 CCNA2 CCND3 CMYA5 DCTN1 DGCR6L DRC12 DST DTNA DTNB ELOVL7 HAUS1 IFT20 IPO5 KALRN KANSL1 KIAA0408 KIFC3 KRT75 MACF1 NBEA NDN NECAB2 NUF2 OIP5 P4HA3 PSME3 RAB11A RBSN SDCBP SFR1 SHFL SNAPIN SRGAP3 SSC5D SYNE1 TNKS TRAF3IP1 TRIM2 TRIM27 TRIM9 VRK2 WASHC3 ZNF490	1 interacting genes: APP
Entrez ID		84062	7172
HPRD ID		06190	01760
Ensembl ID		ENSG00000047579	ENSG00000137364
Uniprot IDs		A0A087WYP9 A0A0S2Z5U8 A6NFV8 D6RJC6 Q96EV8	P51580
PDB IDs			2BZG 2H11
Enriched GO Terms of Interacting Partners?		Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Pigment Granule Localization Axonal Transport Microtubule-based Movement Transport Along Microtubule BLOC-1 Complex Anterograde Synaptic Vesicle Transport Axo-dendritic Transport Cytoskeleton-dependent Intracellular Transport Microtubule-based Process Microtubule-based Transport Establishment Of Vesicle Localization Axon Cytoplasm Microvesicle Vesicle Localization Endosome To Melanosome Transport Plasma Membrane Bounded Cell Projection Organization Synaptic Vesicle Transport Intracellular Transport Melanosome Organization Cellular Localization Nuclear Envelope Pigment Granule Organization Cell Projection Organization Anterograde Axonal Transport Organelle Organization Vesicle Transport Along Microtubule Cytoskeleton Organization Cytoplasm Microtubule Binding Nuclear Membrane Vesicle Cytoskeletal Trafficking Centrosome Establishment Of Protein Localization Cytoskeleton Secretion Of Lysosomal Enzymes Protein Transmembrane Transport Regulation Of Organelle Organization Establishment Of Localization In Cell Positive Regulation Of Pigment Cell Differentiation Spindle Pole Plasma Membrane Bounded Cell Projection Assembly Neuron Projection Development Organelle Transport Along Microtubule Regulation Of Actin Nucleation Cell Projection Assembly Protein Transport	Regulation Of Postsynapse Organization Regulation Of Synapse Organization Positive Regulation Of Receptor Internalization Neuron Projection Development Positive Regulation Of Receptor-mediated Endocytosis Amyloid-beta Complex Regulation Of Plasma Membrane Bounded Cell Projection Organization Growth Cone Lamellipodium Positive Regulation Of Mitotic Cell Cycle Plasma Membrane Bounded Cell Projection Organization Axo-dendritic Transport Regulation Of Cell Projection Organization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Neuron Differentiation Regulation Of Receptor-mediated Endocytosis Cytoplasmic Vesicle Memory Regulation Of Receptor Internalization Positive Regulation Of Transport Nervous System Process Positive Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Parathyroid Hormone Secretion Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Synapse Assembly Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Chemotaxis Cell Maturation Positive Regulation Of Endocytosis Growth Cone Positive Regulation Of Synaptic Transmission Cell Projection Organization Dendritic Spine Heparin Binding Positive Regulation Of Cellular Component Organization Acetylcholine Receptor Activator Activity Transport Along Microtubule Lipoprotein Particle Positive Regulation Of Protein Import Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Regulation Of Lateral Mesodermal Cell Fate Specification Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Regulation Of Neuron Differentiation PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Cytoskeleton-dependent Intracellular Transport Developmental Maturation Regulation Of Chemotaxis
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