CARD14 and UBAC1

Number of citations: 35 (PubMedID 33316896)
Data Source: BioGRID (two hybrid, pull down)

		CARD14	UBAC1
Name		caspase recruitment domain family member 14	UBA domain containing 1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Aggresome	Ubiquitin Ligase Complex Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding CARD Domain Binding	Protein Binding Polyubiquitin Modification-dependent Protein Binding Proteasome Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Apoptotic Process Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity	Protein Ubiquitination Protein Maturation
Pathways		None	Antigen processing: Ubiquitination & Proteasome degradation
GWAS		Fasting glucose ( 34074324 ) Hirschsprung disease ( 26887379 ) Moyamoya disease ( 29273593 ) Psoriasis ( 23143594 )	Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Lung adenocarcinoma (survival time) in never smokers ( 32699080 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Ulcerative colitis ( 28067908 )
Novel Interactors		1 novel interactors: TP53	1 novel interactors: PMPCA
Interacting Genes		7 interacting genes: BCL10 MAP3K1 PRPF31 TRIP13 UBAC1 ZNF471 ZNF648	37 interacting genes: AIRE APP ARRDC3 CARD14 CCDC138 CDKN1B CPSF6 CSNK2A1 DAZAP2 DVL2 FAM168A FAS HOXA2 HTT IGFBP6 LAPTM5 MAP3K1 MCM10 MECOM MGAT3 NEDD4L PLAAT2 PLEKHB2 POU6F2 PPP1CB RNF11 RNF123 RNF216 SMURF1 SPART TRIM2 TRIM39 UBC UBQLN2 WWP2 ZDHHC17 ZG16B
Entrez ID		79092	10422
HPRD ID		06235	12170
Ensembl ID		ENSG00000141527	ENSG00000130560
Uniprot IDs		A0A494C0J4 A0A994J6G4 Q9BXL6	A0A140VK64 Q9BSL1
PDB IDs		Not available	2DAI
GO Terms Enriched among Interactors		General Transcription Initiation Factor Binding T Cell Apoptotic Process Cellular Response To Mechanical Stimulus Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Lymphocyte Apoptotic Process Regulation Of Lymphocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Helicase Activity Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of Chromosome Organization Negative Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D Leukocyte Apoptotic Process Protease Binding Polkadots Positive Regulation Of Lymphotoxin A Production Meiotic Recombination Checkpoint Signaling SnRNP Binding U4atac SnRNP Ribonucleoprotein Complex Localization U4atac SnRNA Binding Histone Deacetylase Regulator Activity Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Response To Actinomycin D T Cell Proliferation Involved In Immune Response Regulation Of G1 To G0 Transition Positive Regulation Of Apoptotic Signaling Pathway Glial Cell Apoptotic Process Cellular Response To UV-C ATP-dependent DNA/DNA Annealing Activity CBM Complex Positive Regulation Of Mast Cell Cytokine Production Negative Regulation Of Mature B Cell Apoptotic Process SnoRNA Localization Negative Regulation Of Mitotic Cell Cycle Phase Transition B Cell Lineage Commitment Regulation Of Pentose-phosphate Shunt Spliceosomal Tri-snRNP Complex Mitochondrial DNA Repair Bone Marrow Development Stress-induced Premature Senescence Female Meiosis I U4 SnRNA Binding Response To Mechanical Stimulus	Ubiquitin Protein Ligase Activity Modification-dependent Protein Catabolic Process Protein Ubiquitination Collateral Sprouting In Absence Of Injury Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Catabolic Process Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Regulation Of Protein Metabolic Process Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Macromolecule Catabolic Process Protein Catabolic Process Positive Regulation Of Aggrephagy Transferase Activity Post-translational Protein Modification Negative Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Protein Catabolic Process Apoptotic Process Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Negative Regulation Of Signal Transduction Regulation Of Proteolysis Proteolysis Protein Targeting To Vacuole Potassium Channel Inhibitor Activity Ubiquitin-protein Transferase Activity Regulation Of Programmed Cell Death Identical Protein Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Signal Transduction Establishment Of Protein Localization To Vacuole Protein Targeting To Vacuole Involved In Autophagy Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Metabolic Process Segment Specification Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Collateral Sprouting Regulation Of Developmental Growth Catabolic Process Receptor Catabolic Process