SMIM7 and CHRM4

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		SMIM7	CHRM4
Description		small integral membrane protein 7	cholinergic receptor muscarinic 4
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Plasma Membrane Membrane Dendrite Synapse Postsynaptic Membrane
	Molecular Function		G Protein-coupled Receptor Activity G Protein-coupled Acetylcholine Receptor Activity
	Biological Process		Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Locomotion
Pathways			Muscarinic acetylcholine receptors G alpha (i) signalling events
Drugs			Ziprasidone Amitriptyline Olanzapine Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Procyclidine Loxapine Carbamoylcholine Hyoscyamine Meperidine Imipramine Darifenacin Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Tropicamide Brompheniramine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Promethazine Pilocarpine Doxepin Desipramine Ketamine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin Isopropamide Acetylcholine ALKS 27 Fesoterodine Methacholine Hexocyclium Aclidinium Umeclidinium Trimebutine Dosulepin Viloxazine Etoperidone Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases
GWAS			Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 29483656)
Interacting Genes		2 interacting genes: CHRM4 DRD2	22 interacting genes: B2M CBFA2T3 CD59 CD81 CFTR EEF1A2 ERGIC3 GPRASP1 GRB2 MCL1 METTL9 QSOX1 RAB3A RHBDD2 RTN4 SLC60A1 SMIM7 SNCA SYN2 TM7SF2 TSPAN7 YIPF3
Entrez ID		79086	1132
HPRD ID		14525	00330
Ensembl ID		ENSG00000214046	ENSG00000180720
Uniprot IDs		B7WNH4 Q9BQ49	P08173
PDB IDs			5DSG 6D9H 6KP6 7LD3 7LD4 7TRK 7TRP 7TRQ 7TRS 7V68 7V69 7V6A 8E9X 8FX5 8IYH 8IYW 8JER 8JHN
Enriched GO Terms of Interacting Partners?		Trans-synaptic Signaling Dendrite G Protein-coupled Acetylcholine Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Postsynaptic Membrane Synaptic Signaling Chemical Synaptic Transmission Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Synapse Structural Plasticity Dopamine Binding Regulation Of Renal Sodium Excretion Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Complex Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Negative Regulation Of Dephosphorylation Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Interneuron Migration From The Subpallium To The Cortex Branching Morphogenesis Of A Nerve Negative Regulation Of Dopamine Secretion Positive Regulation Of Neurotransmitter Uptake Regulation Of Dopamine Uptake Involved In Synaptic Transmission Heterotrimeric G-protein Binding Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Dopamine Receptor Signaling Pathway Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Phospholipase C-activating Dopamine Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Synaptic Transmission, Glutamatergic Response To Histamine Regulation Of Dopamine Receptor Signaling Pathway Catecholamine Uptake Dopamine Uptake Adenohypophysis Development Response To Inactivity Negative Regulation Of Neuron Migration Neuron-neuron Synaptic Transmission Peristalsis Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Urine Volume	Membrane Neurotransmitter Secretion Regulation Of Chaperone-mediated Autophagy Golgi Membrane Receptor Internalization Synaptic Vesicle Clustering Positive Regulation Of Exocytosis Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Protein Localization Vesicle-mediated Transport In Synapse Endoplasmic Reticulum Membrane Neurotransmitter Transport Transport Vesicle Negative Regulation Of Autophagy Regulated Exocytosis Positive Regulation Of T Cell Cytokine Production Response To Iron Ion Positive Regulation Of Transport Regulation Of T Cell Cytokine Production MHC Class II Protein Complex Binding Leukocyte Mediated Immunity Amyloid Fibril Formation Regulation Of Cytokine Production Involved In Immune Response Lymphocyte Mediated Immunity Golgi Apparatus Regulation Of Aerobic Respiration Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Macrophage Fusion Vesicle-mediated Transport Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Cholesterol Biosynthetic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Autophagy Positive Regulation Of Lipid Kinase Activity Guanyl-nucleotide Exchange Factor Adaptor Activity Synaptic Vesicle Calcium-ion Regulated Exocytosis Regulation Of Presynaptic Dense Core Granule Exocytosis Regulation Of Vesicle Fusion Synaptic Vesicle Transport Terminal Bouton Signal Release Vesicle Localization Synaptic Vesicle Exocytosis Evoked Neurotransmitter Secretion Synaptic Vesicle Membrane
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