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C1orf50 and AHCY
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
C1orf50
AHCY
Gene Name
chromosome 1 open reading frame 50
adenosylhomocysteinase
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Melanosome
Neuron Projection
Extracellular Vesicular Exosome
Molecular Function
Adenosylhomocysteinase Activity
Adenyl Nucleotide Binding
Identical Protein Binding
Biological Process
Sulfur Amino Acid Metabolic Process
Response To Hypoxia
Chronic Inflammatory Response To Antigenic Stimulus
One-carbon Metabolic Process
Xenobiotic Metabolic Process
Response To Nutrient
S-adenosylhomocysteine Catabolic Process
Methylation
S-adenosylmethionine Cycle
Cellular Nitrogen Compound Metabolic Process
Circadian Sleep/wake Cycle
Small Molecule Metabolic Process
Homocysteine Biosynthetic Process
Pathways
Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)
Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)
Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)
Sulfur amino acid metabolism
Defective UGT1A4 causes hyperbilirubinemia
Metabolic disorders of biological oxidation enzymes
Metabolism of amino acids and derivatives
Phase II conjugation
Methylation
Defective UGT1A1 causes hyperbilirubinemia
Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)
Biological oxidations
Defective GGT1 causes Glutathionuria (GLUTH)
Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)
Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs
Nicotinamide-Adenine-Dinucleotide
(1\'r,2\'s)-9-(2-Hydroxy-3\'-Keto-Cyclopenten-1-Yl)Adenine
3\'-Oxo-Adenosine
D-Eritadenine
Diseases
GWAS
Protein-Protein Interactions
4 interactors:
AHCY
APPBP2
EPM2AIP1
WDYHV1
7 interactors:
ANKRD40
APPBP2
C1orf50
POT1
PXN
TERF1
YWHAQ
Entrez ID
79078
191
HPRD ID
14714
01621
Ensembl ID
ENSG00000164008
ENSG00000101444
Uniprot IDs
Q9BV19
P23526
PDB IDs
1A7A
1LI4
3NJ4
Enriched GO Terms of Interacting Partners
?
Homocysteine Biosynthetic Process
S-adenosylhomocysteine Catabolic Process
Chronic Inflammatory Response To Antigenic Stimulus
S-adenosylmethionine Cycle
Positive Regulation Of Glycogen (starch) Synthase Activity
S-adenosylhomocysteine Metabolic Process
Circadian Sleep/wake Cycle
Homocysteine Metabolic Process
Regulation Of Glycogen (starch) Synthase Activity
Purine Ribonucleoside Catabolic Process
Chronic Inflammatory Response
Positive Regulation Of Glycogen Biosynthetic Process
S-adenosylmethionine Metabolic Process
Circadian Behavior
Rhythmic Behavior
Cellular Modified Amino Acid Catabolic Process
Sulfur Amino Acid Biosynthetic Process
Regulation Of Glycogen Biosynthetic Process
Inflammatory Response To Antigenic Stimulus
Positive Regulation Of Glucose Metabolic Process
Regulation Of Glycogen Metabolic Process
Sulfur Amino Acid Metabolic Process
One-carbon Metabolic Process
Regulation Of Generation Of Precursor Metabolites And Energy
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomerase Activity
Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance
Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Telomerase Activity
Regulation Of Telomere Maintenance
RNA-dependent DNA Replication
Negative Regulation Of DNA Biosynthetic Process
Telomere Maintenance Via Telomere Lengthening
Regulation Of DNA Biosynthetic Process
Negative Regulation Of DNA Replication
Positive Regulation Of Organelle Organization
Telomere Maintenance
Negative Regulation Of Chromosome Organization
Negative Regulation Of DNA Metabolic Process
Positive Regulation Of DNA Strand Elongation
Regulation Of DNA Replication
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Regulation Of Cellular Component Organization
Telomeric Loop Formation
Age-dependent Telomere Shortening
Telomere Formation Via Telomerase
Telomere Maintenance Via Telomere Shortening
Regulation Of Organelle Organization
Regulation Of Chromosome Organization
Telomere Capping
Positive Regulation Of Helicase Activity
Positive Regulation Of Telomerase Activity
Telomere Assembly
Positive Regulation Of Telomere Maintenance Via Telomerase
DNA Replication
Replicative Cell Aging
Negative Regulation Of Transferase Activity
Regulation Of Nuclear Cell Cycle DNA Replication
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Microtubule Polymerization
Signal Complex Assembly
Positive Regulation Of DNA Biosynthetic Process
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Growth Hormone Receptor Signaling Pathway
Cellular Response To Growth Hormone Stimulus
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Microtubule Polymerization
Focal Adhesion Assembly
Positive Regulation Of Transferase Activity
Cellular Component Assembly
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Process
Tagcloud
?
advantageous
altered
biomarkers
candidates
crc
differentially
discover
earlier
intensities
labeled
lgals1
mining
nbs
near
nitrobenzenesulfenyl
occurring
pair
paired
peaks
profiling
proteome
proteomic
quantified
ran
rcn1
stroma
validated
vim
zyx
Tagcloud (Difference)
?
advantageous
altered
biomarkers
candidates
crc
differentially
discover
earlier
intensities
labeled
lgals1
mining
nbs
near
nitrobenzenesulfenyl
occurring
pair
paired
peaks
profiling
proteome
proteomic
quantified
ran
rcn1
stroma
validated
vim
zyx
Tagcloud (Intersection)
?