PVRIG and OLFM4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PVRIG	OLFM4
Description		PVR related immunoglobulin domain containing	olfactomedin 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Extracellular Space Nucleoplasm Mitochondrion Cytosol Plasma Membrane Secretory Granule Protein-containing Complex Specific Granule Lumen Specific Granule Azurophil Granule Intercellular Bridge Perinuclear Region Of Cytoplasm Extracellular Exosome Tertiary Granule Lumen
	Molecular Function	Protein Binding Phosphatase Binding Signaling Receptor Activity	Structural Molecule Activity Protein Binding Cadherin Binding
	Biological Process	Negative Regulation Of T Cell Receptor Signaling Pathway	Immune Response Cell Adhesion Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Immune Response Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways			Neutrophil degranulation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Ticagrelor levels in individuals with acute coronary syndromes treated with ticagrelor ( 25935875)	Adult body size ( 32376654) Adventurousness ( 30643258) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 29381148 24861553 25673413 25953783 28448500 26961502) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body size at age 10 ( 32376654) Cerebrospinal P-tau181p levels ( 28247064) Childhood body mass index ( 26604143) Depression ( 29700475) Hip circumference ( 25673412) Immune response to anthrax vaccine ( 22658931) Intelligence (MTAG) ( 29326435) Major depressive disorder ( 27479909) Multisite chronic pain ( 33830993) Obesity ( 23563607 22484627) Obesity-related traits ( 23251661) Waist circumference ( 25673412)
Interacting Genes		2 interacting genes: CFTR OLFM4	36 interacting genes: APP AQP2 AQP3 BSCL2 C3 CFTR CLDN7 CLEC17A CLEC7A CLSTN3 CLTRN CREB3L1 EREG FAM209A FNDC9 IL11RA ITM2C KASH5 KIR2DL3 KIR3DL3 LDLRAD1 LEUTX LHFPL2 PVR PVRIG QPCTL SAR1A SLC18A1 SLC22A23 SUSD3 SYNE4 TFR2 TMEM130 TNFSF11 TNFSF14 TSPAN18
Entrez ID		79037	10562
HPRD ID		18875	06580
Ensembl ID		ENSG00000213413	ENSG00000102837
Uniprot IDs		A0A8V8TN58 Q6DKI7	Q6UX06
PDB IDs		8X6B
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Azurophil Granule Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Specific Granule Cellular Response To Forskolin Response To Forskolin Protein-containing Complex Chloride Transmembrane Transporter Activity Sperm Capacitation Bicarbonate Transport Water Transport Multicellular Organismal-level Water Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process 14-3-3 Protein Binding Fluid Transport Transepithelial Transport Vesicle Docking Involved In Exocytosis Positive Regulation Of Transporter Activity ABC-type Transporter Activity Sterol Biosynthetic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Chloride Channel Complex Positive Regulation Of Biomineral Tissue Development Tertiary Granule Lumen Cellular Response To CAMP Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Vesicle Docking Specific Granule Lumen Regulation Of Substrate Adhesion-dependent Cell Spreading Cholesterol Transport Clathrin-coated Endocytic Vesicle Membrane	Membrane Plasma Membrane Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Receptor Ligand Activity Multicellular Organismal-level Chemical Homeostasis Water Transport Multicellular Organismal-level Water Homeostasis Fluid Transport Glycerol Transmembrane Transport Multicellular Organismal-level Homeostasis Renal Water Transport Polyol Transmembrane Transport Meiotic Nuclear Membrane Microtubule Tethering Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Yeast Cell Maturation Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Endocytosis Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Neuron Remodeling Water Channel Activity Organic Hydroxy Compound Transport Positive Regulation Of Defense Response Cell Surface Regulation Of Immune System Process Renal Water Homeostasis
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