RDH10 and DDA1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RDH10	DDA1
Description		retinol dehydrogenase 10	DET1 and DDB1 associated 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Membrane	Nucleoplasm Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	All-trans-retinol Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor All-trans-retinol Dehydrogenase (NADP+) Activity	Protein Binding
	Biological Process	Retinoid Metabolic Process Metanephros Development In Utero Embryonic Development Retinoic Acid Biosynthetic Process Lipid Metabolic Process Visual Perception Gonad Development Animal Organ Morphogenesis Regulation Of Hormone Levels Neural Crest Cell Development Embryonic Camera-type Eye Development Embryonic Forelimb Morphogenesis Retinol Metabolic Process Retinal Metabolic Process Ear Development Nose Development Embryonic Organ Development Embryonic Viscerocranium Morphogenesis Primary Lung Bud Formation Bud Elongation Involved In Lung Branching Positive Regulation Of Retinoic Acid Biosynthetic Process	Protein Polyubiquitination Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		The canonical retinoid cycle in rods (twilight vision) RA biosynthesis pathway	Neddylation
Drugs
Diseases
GWAS		Anthracycline-induced cardiotoxicity in early breast cancer ( 32378780) Ceramide levels (C24:0) ( 32489964) Crohn's disease ( 22412388) Refractive error ( 32231278) Systolic blood pressure ( 30578418)	Mitochondrial DNA copy number ( 30704525) Systemic lupus erythematosus ( 23273568)
Interacting Genes		4 interacting genes: ACSF2 DDA1 GAD2 RMDN2	6 interacting genes: AGTRAP CMTM5 CUL4B LNX2 PKNOX2 RDH10
Entrez ID		157506	79016
HPRD ID		07605	15107
Ensembl ID		ENSG00000121039	ENSG00000130311
Uniprot IDs		Q8IZV5	Q9BW61
PDB IDs			6DSZ 6PAI 6Q0R 6Q0V 6Q0W 6SJ7 6UD7 6UE5 8G46 8QH5 8ROX 8ROY 8TL6 9BZ0 9DHD 9FD2
Enriched GO Terms of Interacting Partners?		Gamma-aminobutyric Acid Biosynthetic Process L-glutamate Catabolic Process Gamma-aminobutyric Acid Metabolic Process Carbon-carbon Lyase Activity Succinate Metabolic Process Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Medium-chain Fatty Acid-CoA Ligase Activity Long-chain Fatty Acid-CoA Ligase Activity Dicarboxylic Acid Catabolic Process Monocarboxylic Acid Metabolic Process Carboxy-lyase Activity	Primary Lung Bud Formation Positive Regulation Of Retinoic Acid Biosynthetic Process
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