RDH10 and ACSF2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RDH10	ACSF2
Description		retinol dehydrogenase 10	acyl-CoA synthetase family member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Membrane	Mitochondrion Mitochondrial Matrix
	Molecular Function	All-trans-retinol Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor All-trans-retinol Dehydrogenase (NADP+) Activity	Nucleotide Binding Catalytic Activity Long-chain Fatty Acid-CoA Ligase Activity Protein Binding ATP Binding Ligase Activity Medium-chain Fatty Acid-CoA Ligase Activity
	Biological Process	Retinoid Metabolic Process Metanephros Development In Utero Embryonic Development Retinoic Acid Biosynthetic Process Lipid Metabolic Process Visual Perception Gonad Development Animal Organ Morphogenesis Regulation Of Hormone Levels Neural Crest Cell Development Embryonic Camera-type Eye Development Embryonic Forelimb Morphogenesis Retinol Metabolic Process Retinal Metabolic Process Ear Development Nose Development Embryonic Organ Development Embryonic Viscerocranium Morphogenesis Primary Lung Bud Formation Bud Elongation Involved In Lung Branching Positive Regulation Of Retinoic Acid Biosynthetic Process	Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Acyl-CoA Metabolic Process
Pathways		The canonical retinoid cycle in rods (twilight vision) RA biosynthesis pathway	Mitochondrial Fatty Acid Beta-Oxidation
Drugs
Diseases
GWAS		Anthracycline-induced cardiotoxicity in early breast cancer ( 32378780) Ceramide levels (C24:0) ( 32489964) Crohn's disease ( 22412388) Refractive error ( 32231278) Systolic blood pressure ( 30578418)	Heel bone mineral density ( 30598549)
Interacting Genes		4 interacting genes: ACSF2 DDA1 GAD2 RMDN2	19 interacting genes: AGTRAP APOA5 APOC1 ARL13B ARL6IP1 C10orf67 CLEC10A CMTM5 COQ9 CREB3 DGAT2L6 GPR152 MICOS13 RDH10 RHBDD2 SENP2 SIGLEC12 SYNGR3 USP40
Entrez ID		157506	80221
HPRD ID		07605	13380
Ensembl ID		ENSG00000121039	ENSG00000167107
Uniprot IDs		Q8IZV5	B4DTB9 E9PF16 Q96CM8
PDB IDs
Enriched GO Terms of Interacting Partners?		Gamma-aminobutyric Acid Biosynthetic Process L-glutamate Catabolic Process Gamma-aminobutyric Acid Metabolic Process Carbon-carbon Lyase Activity Succinate Metabolic Process Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Medium-chain Fatty Acid-CoA Ligase Activity Long-chain Fatty Acid-CoA Ligase Activity Dicarboxylic Acid Catabolic Process Monocarboxylic Acid Metabolic Process Carboxy-lyase Activity	Phosphatidylcholine-sterol O-acyltransferase Activator Activity Very-low-density Lipoprotein Particle Clearance Acylglycerol Metabolic Process Chylomicron Neutral Lipid Metabolic Process Phospholipid Efflux Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Regulation Of Ketone Metabolic Process Plasma Lipoprotein Particle Clearance Acylglycerol Homeostasis Protein-containing Complex Remodeling Lipoprotein Metabolic Process Phosphatidylcholine Binding Cholesterol Efflux Triglyceride Homeostasis Regulation Of Triglyceride Metabolic Process Plasma Lipoprotein Particle Remodeling Negative Regulation Of Phosphatidylcholine Catabolic Process Endoplasmic Reticulum Membrane Positive Regulation Of Deacetylase Activity Isoprenoid Binding Primary Lung Bud Formation Positive Regulation Of Retinoic Acid Biosynthetic Process Regulation Of Lipid Biosynthetic Process Regulation Of Fatty Acid Biosynthetic Process Regulation Of Lipid Catabolic Process Triglyceride Metabolic Process Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Lipase Activator Activity Endoplasmic Reticulum Unfolded Protein Response Cholesterol Transport Regulation Of Phosphatidylcholine Catabolic Process Membrane Lipoprotein Particle Receptor Binding Lipoprotein Lipase Activator Activity Receptor Localization To Non-motile Cilium Acylglycerol Acyl-chain Remodeling Sterol Transport Alcohol Metabolic Process
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