SEMA3B and PAK6

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SEMA3B	PAK6
Description		semaphorin 3B	p21 (RAC1) activated kinase 6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Plasma Membrane Extracellular Matrix	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Cell Junction
	Molecular Function	Protein Binding Semaphorin Receptor Binding Neuropilin Binding Chemorepellent Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Cadherin Binding Protein Serine Kinase Activity
	Biological Process	Neural Crest Cell Migration Cell-cell Signaling Axon Guidance Positive Regulation Of Cell Migration Negative Chemotaxis Chemorepulsion Of Axon Semaphorin-plexin Signaling Pathway	Regulation Of DNA-templated Transcription Apoptotic Process Cytoskeleton Organization Learning Memory Locomotory Behavior Cellular Response To Starvation Intracellular Signal Transduction Regulation Of MAPK Cascade Neuron Projection Arborization Neuron Projection Extension
Pathways			Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle RHOV GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		Obese vs. thin ( 30677029) Sleep duration (short sleep) ( 30846698) Waist circumference adjusted for body mass index ( 34021172)	Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)
Interacting Genes		23 interacting genes: BOLL CARD10 CREBBP CYSRT1 HSF2BP KPRP KRTAP1-1 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP19-5 KRTAP5-9 MDFI NAA10 NBPF19 NOTCH2NLA NRP1 NRP2 PAK6 PICK1 RBPMS2 SEMA3A TRIP13	19 interacting genes: APP AR CDC42 CDK1 DAPK1 ESR1 FBXO7 HSF2BP LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RHOJ RHOV SEMA3B SNX2 TPD52L1
Entrez ID		7869	56924
HPRD ID		03179	06426
Ensembl ID		ENSG00000012171	ENSG00000137843
Uniprot IDs		A0A0C4DGV8 B4DEK9 Q13214 Q6PI51	Q9NQU5
PDB IDs			2C30 2ODB 4KS7 4KS8 6QDR 6QDS
Enriched GO Terms of Interacting Partners?		Sympathetic Neuron Projection Guidance Trigeminal Nerve Structural Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Sympathetic Neuron Projection Extension Intermediate Filament Branchiomotor Neuron Axon Guidance Facial Nerve Structural Organization Sympathetic Ganglion Development Axon Extension Involved In Axon Guidance Ganglion Development Vestibulocochlear Nerve Structural Organization Anatomical Structure Arrangement Dorsal Root Ganglion Morphogenesis Sensory Neuron Axon Guidance Facioacoustic Ganglion Development Neuron Projection Arborization Ventral Trunk Neural Crest Cell Migration Neuron Projection Extension Basal Dendrite Arborization Basal Dendrite Morphogenesis Motor Neuron Axon Guidance Trigeminal Ganglion Development Cranial Ganglion Development Trunk Neural Crest Cell Migration Developmental Cell Growth Semaphorin-plexin Signaling Pathway Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Developmental Growth Involved In Morphogenesis Axon Extension Vascular Endothelial Growth Factor Receptor Activity Female Meiosis I Hypothalamus Cell Migration Neural Crest Cell Migration Mesenchymal Cell Migration Axonogenesis Involved In Innervation N-terminal Protein Amino Acid Acetylation Dendrite Arborization Semaphorin Receptor Activity Semaphorin Receptor Complex Regulation Of Axon Extension Involved In Axon Guidance Sympathetic Nervous System Development Keratin Filament Identical Protein Binding Acetyltransferase Activity Tissue Development Vascular Endothelial Growth Factor Signaling Pathway Female Meiotic Nuclear Division Developmental Process Male Meiosis I Outflow Tract Septum Morphogenesis	Intracellular Signal Transduction Anatomical Structure Morphogenesis Developmental Process Cellular Response To Estrogen Stimulus Protein Kinase Binding Supramolecular Fiber Organization Regulation Of Mitotic Cell Cycle Protein-containing Complex Protein Serine Kinase Activity Glutamatergic Synapse Protein Serine/threonine Kinase Activity Intracellular Signaling Cassette Cell Communication Regulation Of Signal Transduction Regulation Of Cell Cycle Phase Transition Developmental Growth Involved In Morphogenesis Regulation Of Developmental Process Regulation Of Developmental Growth Regulation Of Intracellular Signal Transduction Estrogen Response Element Binding Prostate Gland Growth Response To Estrogen Mitotic Nuclear Membrane Disassembly Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Cell Cycle Process Protein Kinase Activity Ubiquitin Protein Ligase Binding Positive Regulation Of Cell Cycle Cellular Developmental Process Regulation Of Locomotion Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Protein Localization To Kinetochore Regulation Of Reproductive Process Positive Regulation Of Cell Migration Developmental Growth Regulation Of Growth Regulation Of MiRNA Transcription Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Reproductive Process Membrane Disassembly Nuclear Membrane Disassembly Leukocyte Differentiation GTP Binding Cell-cell Signaling Cellular Response To Oxygen-containing Compound Regulation Of Apoptotic Signaling Pathway
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