CACNG1 and MGST3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CACNG1	MGST3
Description		calcium voltage-gated channel auxiliary subunit gamma 1	microsomal glutathione S-transferase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Calcium Channel Complex Membrane T-tubule Monoatomic Ion Channel Complex Sarcolemma L-type Voltage-gated Calcium Channel Complex	Nuclear Envelope Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Voltage-gated Calcium Channel Activity Calcium Channel Regulator Activity Calcium Channel Activity Protein Binding	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Oxidoreductase Activity Transferase Activity Lyase Activity Identical Protein Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Monoatomic Ion Transmembrane Transport Positive Regulation Of Muscle Contraction Establishment Of Localization In Cell Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel	Lipid Metabolic Process Leukotriene Metabolic Process Prostanoid Metabolic Process Arachidonate Metabolic Process Leukotriene Biosynthetic Process Cellular Oxidant Detoxification
Pathways			Glutathione conjugation Aflatoxin activation and detoxification
Drugs		Ergocalciferol Enflurane Ibutilide Diltiazem Spironolactone Lercanidipine Nicardipine Verapamil Ethanol Fluspirilene Efonidipine Butamben Bioallethrin	Glutathione
Diseases
GWAS		Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Metabolite levels ( 23823483) Total ventricular volume ( 21116278)
Interacting Genes		13 interacting genes: CPLX4 FFAR2 GAD2 GPX8 HSD17B13 LMNA MGST3 MUC1 ODF4 THAP4 TLCD4 TMEM45B VAPA	86 interacting genes: AGPAT4 AGTRAP APOD APOL2 AQP1 AQP10 AQP3 ARL6IP1 ARL6IP6 BET1 BMP10 C11orf24 C14orf180 C3orf52 CACNG1 CCNC CDIPT CLCA4 CLRN1 CMTM5 CREB3L1 CTSA CYBC1 ERG28 F10 FAXDC2 FUNDC2 FXYD6 GIMAP1 GIMAP5 GPR152 GPX8 GRM2 HMOX2 ITGAM LEMD1 LMNA LPAR3 LRP10 MIP MRM1 MTIF3 NEU1 NINJ2 NKG7 NRM NSG1 PAGE1 PLN PLP1 PLP2 PLPP4 SCD SCN3B SEC22B SLC1A3 SLC2A5 SLC35A1 SLC39A9 SLC7A1 SMCO4 SNAP47 SNORC STX3 STX7 STX8 SYS1 TFAM TFRC TMEM107 TMEM109 TMEM120B TMEM140 TMEM229B TMEM60 TMEM86B TMX2 TSPAN12 TSPAN2 TSPAN33 UBIAD1 UNC50 VAMP3 VAMP4 YIF1A ZFPL1
Entrez ID		786	4259
HPRD ID		00249	05192
Ensembl ID		ENSG00000108878	ENSG00000143198
Uniprot IDs		Q06432	O14880 Q5VV89
PDB IDs
Enriched GO Terms of Interacting Partners?			Membrane SNAP Receptor Activity SNARE Complex Endoplasmic Reticulum Membrane Protein Binding Endoplasmic Reticulum Water Channel Activity Plasma Membrane Glycerol Transmembrane Transport Organelle Fusion Water Transport Polyol Transmembrane Transport Vesicle Fusion Membrane Fusion Organelle Membrane Fusion Fluid Transport Vesicle Organization Channel Activity Endomembrane System Vesicle-mediated Transport Carbohydrate Transmembrane Transport Carbohydrate Transport Nuclear Inner Membrane Transport Vesicle Establishment Of Protein Localization To Plasma Membrane Glycerol Channel Activity Vesicle Docking One-carbon Compound Transport Acute Inflammatory Response Renal Water Absorption Urea Transmembrane Transporter Activity IgG Receptor Activity Protein Localization To Plasma Membrane Membrane Organization Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Chloride Channel Inhibitor Activity Renal Water Transport Antibody-dependent Cellular Cytotoxicity Fc-gamma Receptor Signaling Pathway Organelle Localization By Membrane Tethering Response To Hypoxia Golgi To Plasma Membrane Protein Transport Urea Transmembrane Transport Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Response To Decreased Oxygen Levels Ventricular Cardiac Muscle Cell Development Membrane Docking Neurotransmitter Receptor Transport To Postsynaptic Membrane Protein Localization To Cell Periphery
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