SNRNP40 and ACP5

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		SNRNP40	ACP5
Gene Name		small nuclear ribonucleoprotein 40kDa (U5)	acid phosphatase 5, tartrate resistant
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm U5 SnRNP Small Nucleolar Ribonucleoprotein Complex Cytoplasm Catalytic Step 2 Spliceosome	Lysosome Cytosol Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Poly(A) RNA Binding	Acid Phosphatase Activity Ferrous Iron Binding Ferric Iron Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Processing RNA Splicing Gene Expression	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Riboflavin Metabolic Process Dephosphorylation Response To Lipopolysaccharide Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Superoxide Anion Generation Response To Cytokine Small Molecule Metabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Bone Resorption Negative Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Bone Morphogenesis
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway	Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Vitamin B2 (riboflavin) metabolism Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Metabolism of water-soluble vitamins and cofactors Defective MUT causes methylmalonic aciduria mut type Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism
Drugs
Diseases
GWAS		Alcohol dependence ( 23455491)	Multiple sclerosis (severity) ( 19010793)
Protein-Protein Interactions		6 interactors: ACP5 APP DDR1 DHX16 EFTUD2 SNRNP200	11 interactors: EGR2 GPC4 MAPK9 PDCD5 PPP2CB RPA2 SLC35F6 SNRNP40 SPP1 TNFSF10 ZBTB16
Entrez ID		9410	54
HPRD ID		08481	01374
Ensembl ID		ENSG00000060688	ENSG00000102575
Uniprot IDs		A0MNP2 B4DQJ1 Q96DI7	P13686
PDB IDs			1WAR 2BQ8
Enriched GO Terms of Interacting Partners?		MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing Smooth Muscle Cell-matrix Adhesion Cis Assembly Of Pre-catalytic Spliceosome Negative Regulation Of Superoxide Anion Generation Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Riboflavin Metabolic Process Axon Choice Point Recognition Heterocycle Metabolic Process Collagen-activated Signaling Pathway Cellular Nitrogen Compound Metabolic Process Neuron Remodeling Smooth Muscle Cell Migration Regulation Of Extracellular Matrix Disassembly Regulation Of Superoxide Anion Generation Negative Regulation Of Interleukin-1 Beta Production Nitrogen Compound Metabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Extracellular Matrix Organization Extracellular Structure Organization RNA Metabolic Process Negative Regulation Of Reactive Oxygen Species Biosynthetic Process MRNA Cis Splicing, Via Spliceosome Cellular Copper Ion Homeostasis Negative Regulation Of Interleukin-12 Production Wound Healing, Spreading Of Cells Regulation Of Extracellular Matrix Organization Gene Expression Muscle Cell Migration Copper Ion Homeostasis Suckling Behavior Cellular Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Mammary Gland Lobule Development Mammary Gland Alveolus Development Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Branching Involved In Mammary Gland Duct Morphogenesis	Regulation Of Mitochondrion Organization Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Cell Death Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Proteolysis Positive Regulation Of Mitochondrion Organization Response To Organic Substance Apoptotic Mitochondrial Changes Rhombomere 5 Formation Rhombomere 3 Formation Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of Protein Import Into Mitochondrial Outer Membrane Negative Regulation Of Chaperone-mediated Protein Folding Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Rhombomere 3 Morphogenesis Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of Cellular Component Organization Zymogen Activation Regulation Of Signaling Brain Segmentation Regulation Of Protein Targeting To Mitochondrion Rhombomere 3 Development Rhombomere 5 Development Cellular Response To Growth Factor Stimulus Rhombomere Morphogenesis Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of NK T Cell Differentiation DNA Recombinase Assembly JUN Phosphorylation Response To Growth Factor Cellular Response To Stimulus Positive Regulation Of Prostaglandin Biosynthetic Process Male Germ-line Stem Cell Asymmetric Division
Tagcloud ?			13qter 9p cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgam itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1
Tagcloud (Difference) ?			13qter 9p cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgam itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1
Tagcloud (Intersection) ?