CA12 and ATP5C1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CA12	ATP5C1
Gene Name		carbonic anhydrase XII	ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Mitochondrial Proton-transporting ATP Synthase Complex, Catalytic Core F(1) Mitochondrion Mitochondrial Inner Membrane Mitochondrial Proton-transporting ATP Synthase Complex Mitochondrial Matrix Membrane Extracellular Vesicular Exosome
	Molecular Function	Carbonate Dehydratase Activity Zinc Ion Binding	ATPase Activity Transmembrane Transporter Activity Poly(A) RNA Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	One-carbon Metabolic Process Bicarbonate Transport Small Molecule Metabolic Process Chloride Ion Homeostasis	Oxidative Phosphorylation ATP Biosynthetic Process Respiratory Electron Transport Chain Mitochondrial ATP Synthesis Coupled Proton Transport Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Reversible hydration of carbon dioxide	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. The citric acid (TCA) cycle and respiratory electron transport Formation of ATP by chemiosmotic coupling
Drugs		Benzthiazide Hydroflumethiazide Zonisamide Hydrochlorothiazide Ellagic Acid
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ATP5C1 CUX1 DAXX KATNBL1 LGALS7 MAPK6 MRPL9 RDH11 SGSM2 TOE1	23 interactors: APP ATP5A1 ATP5B CA12 CCND3 CCT7 CHMP2B DPP3 EGFR ELOF1 GDPD2 ITIH2 MED15 MPP1 NDUFB3 NGEF PAWR PJA1 PNO1 POLA2 PTN SERPINA1 ZNF337
Entrez ID		771	509
HPRD ID		04464	00156
Ensembl ID			ENSG00000165629
Uniprot IDs		B3KUB4 O43570	P36542 Q8TAS0
PDB IDs		1JCZ 1JD0 4HT2
Enriched GO Terms of Interacting Partners?			Mitochondrial ATP Synthesis Coupled Proton Transport Respiratory Electron Transport Chain Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Electron Transport Chain ATP Metabolic Process ATP Synthesis Coupled Proton Transport Cellular Respiration ATP Biosynthetic Process Alkanesulfonate Metabolic Process Response To Methanol Purine Nucleoside Metabolic Process Ion Homeostasis Nucleotide Metabolic Process Negative Regulation Of Endopeptidase Activity Learning Or Memory Negative Regulation Of Peptidase Activity ATP Hydrolysis Coupled Proton Transport Synaptic Growth At Neuromuscular Junction Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Response To Triglyceride Astrocyte Activation Platelet Degranulation Purine Ribonucleoside Monophosphate Biosynthetic Process Ossification Positive Regulation Of Cell Cycle Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cognition Ribonucleotide Metabolic Process Nucleoside Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Nucleobase-containing Small Molecule Metabolic Process Purine Nucleotide Metabolic Process Regulation Of ERBB Signaling Pathway Negative Regulation Of Dendritic Spine Morphogenesis Collateral Sprouting In Absence Of Injury Nucleoside Triphosphate Biosynthetic Process Ribose Phosphate Metabolic Process Cell Activation Ribonucleoside Monophosphate Biosynthetic Process Small Molecule Metabolic Process Activation Of Phospholipase A2 Activity Response To Chromate Negative Regulation Of Proteolysis Cellular Metabolic Process Regulation Of Catalytic Activity Nucleobase-containing Compound Metabolic Process Nucleoside Monophosphate Biosynthetic Process Negative Regulation Of Protein Processing Cellular Localization
Tagcloud ?		adenocarcinoma adenosquamous bilateral cea cervix chemoradiotherapy ck5 ck7 concurrent dissection distant hysterectomy intracolposcopic irregular lymphadenectomy nodes oophorectomy papillary pelvic poorer postoperative ppsc pure rarely salpingo serous unpredictable vaginal woman	3xflag compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases pp1 ppp1ca ppp1cb ppp1cc ppp1cc1 ppp1cc2 reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously
Tagcloud (Difference) ?		adenocarcinoma adenosquamous bilateral cea cervix chemoradiotherapy ck5 ck7 concurrent dissection distant hysterectomy intracolposcopic irregular lymphadenectomy nodes oophorectomy papillary pelvic poorer postoperative ppsc pure rarely salpingo serous unpredictable vaginal woman	3xflag compatible created creating ddost deleted dissociated envelope immunolocalization knock mammals persists phosphatases pp1 ppp1ca ppp1cb ppp1cc ppp1cc1 ppp1cc2 reciprocal sbp sedimentation spermatogenesis spermatogenic splice tagged tandem testis ubiquitously
Tagcloud (Intersection) ?