ZBTB17 and MTHFR

Data Source: HiPPIP (Novel)

		ZBTB17	MTHFR
Name		zinc finger and BTB domain containing 17	methylenetetrahydrofolate reductase
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Protein-containing Complex Protein-DNA Complex	Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding DNA-binding Transcription Factor Binding	Catalytic Activity Methylenetetrahydrofolate Reductase [NAD(P)H] Activity Protein Binding Oxidoreductase Activity Protein-containing Complex Binding Flavin Adenine Dinucleotide Binding NADP Binding FAD Binding Modified Amino Acid Binding Methylenetetrahydrofolate Reductase (NADPH) Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Gastrulation With Mouth Forming Second Regulation Of Cytokine Production Regulation Of Immune System Process Ectoderm Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II G1 To G0 Transition	Response To Hypoxia Neural Tube Closure Methionine Metabolic Process Methionine Biosynthetic Process Response To Xenobiotic Stimulus Response To Vitamin B2 Tetrahydrofolate Interconversion Response To Amino Acid S-adenosylmethionine Metabolic Process Tetrahydrofolate Metabolic Process Homocysteine Metabolic Process Response To Folic Acid Response To Interleukin-1 Heterochromatin Organization
Pathways		XBP1(S) activates chaperone genes	Metabolism of folate and pterines
Drugs		None	Cyanocobalamin Tetrahydrofolic acid
Diseases		None	Spina bifida Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Homocystinuria
GWAS		Dilated cardiomyopathy ( 33495596 ) Dilated cardiomyopathy (MTAG) ( 33495596 ) Erectile dysfunction ( 30583798 ) Glomerular filtration rate ( 29403010 ) Heel bone mineral density ( 30598549 ) Idiopathic dilated cardiomyopathy ( 21459883 )	Atrial fibrillation ( 19597492 ) Blood pressure ( 21909110 ) Coronary artery disease ( 29212778 ) Diastolic blood pressure ( 29615537 28739976 27841878 27618452 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Early-onset schizophrenia ( 33907183 ) Folate pathway vitamin levels ( 19744961 ) High altitude adaptation ( 28373541 ) Hip index ( 34021172 ) Homocysteine levels ( 20031578 23696881 23824729 ) Hypertension ( 31879980 ) Mean arterial pressure ( 27618448 ) Mean corpuscular hemoglobin ( 32888494 ) Mean platelet volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (calcium channel blockers) ( 31015401 ) Midregional pro atrial natriuretic peptide levels ( 29237677 ) Moyamoya disease ( 29273593 ) Multiple sclerosis ( 31604244 ) Offspring birth weight ( 31043758 ) Plasma homocysteine levels ( 30339177 ) Pulse pressure ( 27841878 ) Red blood cell count ( 32888494 ) Red blood cell folate levels ( 30339177 ) Serum folate levels ( 29953918 30339177 ) Systolic blood pressure ( 27618452 28739976 19430483 27618447 27841878 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Tuberculosis ( 29036319 )
Novel Interactors		2 novel interactors: MTHFR RERE	7 novel interactors: DDX21 FHL2 MMP23B PRKCZ TP73 ZBTB17 ZNF239
Interacting Genes		28 interacting genes: BCL6 CDKN2B CREBBP DIS3 DNMT3A E2F6 EP300 ESR1 ESR2 GTF2I HCFC1 HK2 HK3 HSPB1 IRF8 ITGB5 MAX MSX2 MYC MYCN PGR TMPRSS11A TOPBP1 TRIM55 TRIM63 VHL ZBTB7C ZBTB8A	1 interacting genes: LSM8
Entrez ID		7709	4524
HPRD ID		04968	06158
Ensembl ID		ENSG00000116809	ENSG00000177000
Uniprot IDs		Q13105 Q53EM1	A0A286YFD0 P42898 Q59GJ6 Q5SNW7 Q8IU67
PDB IDs		2LVR 2LVT 2LVU 2M0D 2M0E 2M0F 2N25 2N26 2Q81 3M52 4U2M 4U2N 5ION 7AZW 7AZX 7MC1 7MC2 7MC3 7T58	6FCX 8QA4 8QA5 8QA6
GO Terms Enriched among Interactors		Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Transcription Coactivator Binding Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Chromatin Organization DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Estrogen Response Element Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Response To Decreased Oxygen Levels Chromatin Chromatin Remodeling Regulation Of Gene Expression Response To Oxygen Levels Regulation Of Macromolecule Biosynthetic Process Histone H3K27 Acetyltransferase Activity Myc-Max Complex Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nuclear Steroid Receptor Activity Morphogenesis Of A Branching Structure Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Histone Acetyltransferase Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process	None