ZNF148 and USP54

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF148	USP54
Description		zinc finger protein 148	ubiquitin specific peptidase 54
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cellular Defense Response Gamete Generation Negative Regulation Of Gene Expression Substantia Nigra Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Proteolysis Protein Deubiquitination
Pathways
Drugs
Diseases
GWAS		Urate levels ( 31578528)	Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		25 interacting genes: CAVIN1 CEP63 CEP70 CLK1 DEUP1 EP300 GLRX3 GORASP2 JADE1 KRT31 KRT34 LNX1 LNX2 NUTM2F PFDN5 PLEKHG4 PNMA1 POU6F2 SIAH1 STAT3 TP53 TRIM10 UBC USP54 ZMYND12	89 interacting genes: ANKRD11 ANKS1A ARMC7 ATN1 ATXN1 ATXN1L ATXN7L2 BFSP2 BHLHE40 CARD10 CCDC13 CCDC24 CCNK CDC23 CHCHD2 CHERP CHMP1B CHMP2A CHMP2B CHMP4C CSTF2 CYSRT1 DMRT3 DOK6 DTX2 DYRK1A EIF4E2 EPM2AIP1 EXOC8 FAM124B FBXO17 FNDC3B FOXI1 GCM2 HGS HNF1B HNRNPF HOXC8 IGFN1 INSC KCTD9 LMO3 LNX1 MED25 MID2 NUDT22 NXT2 OIP5 OTX1 PCSK5 PHF1 PLA2G6 PLAC8 PLEKHN1 POLR1C PRDM6 PRKAB2 PRR35 QRICH1 RACK1 RAMAC RBPMS2 RHOBTB3 RNF208 SEC24A SHARPIN SHC3 SMARCD1 SMYD1 SNRPB SS18L1 STK16 TBX6 TCEA2 TEKT5 TENT5B TFAP2D TLE5 TNS2 TOLLIP TSEN15 TSSK3 TTC19 UBC USP2 VENTX ZCCHC14 ZNF148 ZNF76
Entrez ID		7707	159195
HPRD ID		03540	15641
Ensembl ID		ENSG00000163848	ENSG00000166348
Uniprot IDs		Q9UQR1	A0A7P0T9K1 B7Z7X1 Q70EL1
PDB IDs			8C61
Enriched GO Terms of Interacting Partners?		T Cell Lineage Commitment De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation De Novo Centriole Assembly Negative Regulation Of MiRNA Processing Regulation Of Carbohydrate Catabolic Process Regulation Of Purine Nucleotide Metabolic Process T-helper 17 Cell Lineage Commitment Negative Regulation Of MiRNA-mediated Gene Silencing Regulation Of MiRNA Processing Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Regulation Of Regulatory NcRNA Processing T-helper Cell Lineage Commitment CD4-positive, Alpha-beta T Cell Lineage Commitment System Development Organelle Organization Histone Acetyltransferase Complex CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Autophagy Negative Regulation Of Small Molecule Metabolic Process Organelle Assembly Alpha-beta T Cell Lineage Commitment Identical Protein Binding Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing RRNA Transcription Centriole Replication Centriole Assembly Regulation Of Generation Of Precursor Metabolites And Energy Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Peptidyl-lysine Propionylation Nervous System Development Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity RNA Polymerase III Assembly RNA Polymerase I Assembly Negative Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Cell Differentiation Cellular Component Assembly	Membrane Fission ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Multivesicular Body Membrane Multivesicular Body-lysosome Fusion Viral Budding From Plasma Membrane Multivesicular Body Assembly Lysosomal Membrane Organization Multivesicular Body Organization Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Late Endosome To Lysosome Transport Kinetochore Microtubule Mitotic Metaphase Chromosome Alignment Endosome Organization Multivesicular Body Sorting Pathway Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Midbody Abscission Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process Protein Binding Metaphase Chromosome Alignment Plasma Membrane Repair ESCRT III Complex Disassembly Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Release From Host Cell ESCRT Complex Disassembly Regulation Of Spindle Assembly Regulation Of Transcription By RNA Polymerase II Cytokinetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Mitotic Spindle Organization Chromosome Localization Regulation Of Macromolecule Biosynthetic Process Multivesicular Body Regulation Of RNA Metabolic Process POZ Domain Binding Regulation Of Centrosome Duplication Nuclear Membrane Organization Regulation Of Primary Metabolic Process Autophagosome Maturation Autophagosome Membrane Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process
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