EMSY and ZNF131

Number of citations of the paper that reports this interaction (PubMedID 26841866)
31

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		EMSY	ZNF131
Description		EMSY transcriptional repressor, BRCA2 interacting	zinc finger protein 131
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Intermediate Filament Cytoskeleton
	Molecular Function	Protein Binding Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	DNA Repair Chromatin Organization Regulation Of DNA-templated Transcription DNA Damage Response	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways			SUMOylation of transcription cofactors
Drugs
Diseases
GWAS		Allergic rhinitis ( 31361310) Asthma ( 29273806 31361310 31959851 34103634) Asthma (adult onset) ( 31036433) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Eczema ( 31361310) Eosinophil count ( 29403010) Eosinophilic esophagitis ( 34506852) Type 1 diabetes ( 34012112)	Body mass index ( 25673413) Mean corpuscular hemoglobin concentration ( 32888494) Menarche (age at onset) ( 25231870)
Interacting Genes		14 interacting genes: AIDA AKT1 BRCA2 CBX1 CLVS2 DDIT3 DISC1 GET3 H3-4 LIX1 PSMA1 ZMYND11 ZNF131 ZNF646	8 interacting genes: EMSY FHL2 HSPB1 KPNA2 KPNA3 KPNA6 MORN4 PIP4K2B
Entrez ID		56946	7690
HPRD ID		10544	07239
Ensembl ID		ENSG00000158636	ENSG00000172262
Uniprot IDs		Q7Z589	P52739
PDB IDs		1UTU 1UZ3 2FMM
Enriched GO Terms of Interacting Partners?		PERK-mediated Unfolded Protein Response	Viral Penetration Into Host Nucleus Intracellular Transport Of Virus Host Cell NLS-dependent Protein Nuclear Import Complex Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding NLS-bearing Protein Import Into Nucleus Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Protein Import Into Nucleus Import Into Nucleus Viral Process Intracellular Protein Transport Positive Regulation Of Viral Life Cycle Protein Localization To Nucleus Nuclear Transport Nucleocytoplasmic Transport Positive Regulation Of Viral Process Establishment Of Protein Localization To Organelle Negative Regulation Of Protein Kinase C Signaling Protein Transport Atrial Cardiac Muscle Cell Development Positive Regulation Of Cytokine Production Protein Kinase C Inhibitor Activity Intracellular Transport Regulation Of Viral Life Cycle 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process 1-phosphatidylinositol-5-phosphate 4-kinase Activity Z Disc Establishment Of Protein Localization Regulation Of Viral Process 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Metabolic Process Regulation Of Protein Kinase C Signaling Protein Localization To Organelle Nucleoplasm Cellular Localization Establishment Of Localization In Cell 1-phosphatidylinositol-4-phosphate 5-kinase Activity Actin-based Cell Projection Anterograde Axonal Protein Transport Ventricular Cardiac Muscle Cell Development Regulation Of Cytokine Production Nucleus Intracellular Protein Localization Phosphatidylinositol Kinase Activity Protein Transport Along Microtubule Contractile Muscle Fiber Heart Trabecula Formation Positive Regulation Of Endothelial Cell Chemotaxis Autophagosome-lysosome Fusion Negative Regulation Of Calcineurin-NFAT Signaling Cascade
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