CA6 and SDHB

		CA6	SDHB
Description		carbonic anhydrase 6	succinate dehydrogenase complex iron sulfur subunit B
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol Extracellular Exosome	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex II (succinate Dehydrogenase)
	Molecular Function	Carbonate Dehydratase Activity Zinc Ion Binding Lyase Activity Metal Ion Binding	Protein Binding Succinate Dehydrogenase (quinone) Activity Electron Transfer Activity Oxidoreductase Activity Metal Ion Binding Ubiquinone Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding 3 Iron, 4 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste	Tricarboxylic Acid Cycle Succinate Metabolic Process Mitochondrial Electron Transport, Succinate To Ubiquinone Aerobic Respiration Respiratory Electron Transport Chain Proton Motive Force-driven Mitochondrial ATP Synthesis
Pathways		Reversible hydration of carbon dioxide	Respiratory electron transport Citric acid cycle (TCA cycle) Maturation of TCA enzymes and regulation of TCA cycle
Drugs		Benzthiazide Cyclothiazide Zonisamide Mafenide Ellagic acid	2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Ubiquinone Q1
Diseases
GWAS		Blood protein levels ( 30072576) Post bronchodilator FEV1 ( 26634245)	A body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 20189936) Hip circumference adjusted for BMI ( 34021172) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		4 interacting genes: FCGRT KRT31 KRT40 NOTCH2NLA	8 interacting genes: ABCA1 CARTPT GEM MSRA PIK3R5 SPRY2 TMEM132D XRN1
Entrez ID		765	6390
HPRD ID		00264	01707
Ensembl ID		ENSG00000131686	ENSG00000117118
Uniprot IDs		B4DUH8 P23280	A0AAQ5BHD9 P21912
PDB IDs		3FE4	7KCL 7KCM 7KLU 7KLV 8GS8
Enriched GO Terms of Interacting Partners?		IgG Immunoglobulin Transcytosis In Epithelial Cells Mediated By FcRn Immunoglobulin Receptor Regulation Of Locomotor Rhythm TFIIIC-class Transcription Factor Complex Binding Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization 3 Iron, 4 Sulfur Cluster Binding Sucrose Transport D-glucose:proton Symporter Activity Sucrose:proton Symporter Activity Galactose:proton Symporter Activity Immunoglobulin Transcytosis In Epithelial Cells Positive Regulation Of Pentose-phosphate Shunt Inositol Hexakisphosphate Binding RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding Negative Regulation Of TORC2 Signaling Negative Regulation Of Lysosome Organization T-helper 1 Cell Lineage Commitment Respiratory Chain Complex II (succinate Dehydrogenase) Succinate Dehydrogenase (quinone) Activity Galactose Transmembrane Transport Positive Regulation Of Cytoplasmic Translational Initiation TORC1 Complex Energy Derivation By Oxidation Of Organic Compounds Regulation Of Pentose-phosphate Shunt Cellular Response To Methionine Voluntary Musculoskeletal Movement 'de Novo' Pyrimidine Nucleobase Biosynthetic Process RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Intermediate Filament Structural Molecule Activity Mitochondrial Electron Transport, Succinate To Ubiquinone Ubiquinone Binding Response To Methionine Succinate Metabolic Process Beta-2-microglobulin Binding Regulation Of NADP Metabolic Process Pyrimidine Nucleobase Biosynthetic Process Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I TORC2 Complex Negative Regulation Of Cell Size Vascular Endothelial Cell Response To Laminar Fluid Shear Stress	Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction
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