CA6 and FCGRT

Number of citations: 0 (PubMedID 9439449)
Data Source: HPRD (in vitro)

		CA6	FCGRT
Name		carbonic anhydrase 6	Fc gamma receptor and transporter
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol Extracellular Exosome	Extracellular Space Endosome Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Membrane
	Molecular Function	Carbonate Dehydratase Activity Zinc Ion Binding Lyase Activity Metal Ion Binding	Protein Binding IgG Binding Beta-2-microglobulin Binding Peptide Antigen Binding
	Biological Process	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste	IgG Immunoglobulin Transcytosis In Epithelial Cells Mediated By FcRn Immunoglobulin Receptor Immune Response
Pathways		Reversible hydration of carbon dioxide	None
Drugs		Benzthiazide Cyclothiazide Zonisamide Mafenide Ellagic acid	Efgartigimod alfa
GWAS		Blood protein levels ( 30072576 ) Post bronchodilator FEV1 ( 26634245 )	Apolipoprotein B levels ( 32203549 ) Aspartate aminotransferase levels ( 29403010 ) Hematocrit ( 32888494 ) Hematological and biochemical traits ( 20139978 ) Hemoglobin ( 32888494 ) Plateletcrit ( 32888494 ) Red blood cell count ( 32888494 ) Reticulocyte count ( 32888494 ) Serum albumin levels ( 23022100 29403010 ) Serum total protein levels ( 23022100 ) Total cholesterol levels ( 29403010 ) Triglyceride levels ( 32203549 )
Novel Interactors		3 novel interactors: MTOR SDHB SLC45A1	None recorded
Interacting Genes		4 interacting genes: FCGRT KRT31 KRT40 NOTCH2NLA	9 interacting genes: ALB B2M CA6 CLDN19 FAM3C MTDH NINJ2 PMP22 UPK2
Entrez ID		765	2217
HPRD ID		00264	03257
Ensembl ID		ENSG00000131686	ENSG00000104870
Uniprot IDs		B4DUH8 P23280	A0A024QZI2 M0R0A9 P55899
PDB IDs		3FE4	1EXU 3M17 3M1B 4K71 4N0F 4N0U 5BJT 5BXF 5WHK 6C97 6C98 6C99 6FGB 6ILM 6LA6 6LA7 6NHA 6QIO 6QIP 6WNA 6WOL 7B5F 7C9V 7Q15 7XXA 9MI6
GO Terms Enriched among Interactors		IgG Immunoglobulin Transcytosis In Epithelial Cells Mediated By FcRn Immunoglobulin Receptor Regulation Of Locomotor Rhythm TFIIIC-class Transcription Factor Complex Binding Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization 3 Iron, 4 Sulfur Cluster Binding Sucrose Transport D-glucose:proton Symporter Activity Sucrose:proton Symporter Activity Galactose:proton Symporter Activity Immunoglobulin Transcytosis In Epithelial Cells Positive Regulation Of Pentose-phosphate Shunt Inositol Hexakisphosphate Binding RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding Negative Regulation Of TORC2 Signaling Negative Regulation Of Lysosome Organization T-helper 1 Cell Lineage Commitment Respiratory Chain Complex II (succinate Dehydrogenase) Succinate Dehydrogenase (quinone) Activity Galactose Transmembrane Transport Positive Regulation Of Cytoplasmic Translational Initiation TORC1 Complex Energy Derivation By Oxidation Of Organic Compounds Regulation Of Pentose-phosphate Shunt Cellular Response To Methionine Voluntary Musculoskeletal Movement 'de Novo' Pyrimidine Nucleobase Biosynthetic Process RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Intermediate Filament Structural Molecule Activity Mitochondrial Electron Transport, Succinate To Ubiquinone Ubiquinone Binding Response To Methionine Succinate Metabolic Process Beta-2-microglobulin Binding Regulation Of NADP Metabolic Process Pyrimidine Nucleobase Biosynthetic Process Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I TORC2 Complex Negative Regulation Of Cell Size Vascular Endothelial Cell Response To Laminar Fluid Shear Stress	Bicellular Tight Junction