ZNF74 and TRIM28

Number of citations of the paper that reports this interaction (PMID 12684500)
11

Data Source:
BioGRID (fluorescent resonance energy transfer)
HPRD (in vivo)

		ZNF74	TRIM28
Gene Name		zinc finger protein 74	tripartite motif containing 28
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Actin Cytoskeleton	Nucleus Nucleoplasm Nuclear Euchromatin Nuclear Heterochromatin RNA Polymerase II Transcription Factor Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Binding Metal Ion Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Kinase Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Krueppel-associated Box Domain Binding Sequence-specific DNA Binding Poly(A) RNA Binding Chromo Shadow Domain Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organismal Development	Negative Regulation Of Transcription From RNA Polymerase II Promoter Epithelial To Mesenchymal Transition DNA Repair Transcription Initiation From RNA Polymerase II Promoter Embryo Implantation Gene Expression Protein Ubiquitination Protein Sumoylation Positive Regulation Of Transcription Factor Import Into Nucleus DNA Methylation Involved In Embryo Development Innate Immune Response Positive Regulation Of DNA Repair Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Oligomerization Convergent Extension Involved In Axis Elongation Embryonic Placenta Morphogenesis Negative Regulation Of DNA Demethylation Negative Regulation Of Viral Release From Host Cell Regulation Of Genetic Imprinting
Pathways		Generic Transcription Pathway	Generic Transcription Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: POLR2A TRIM28	62 interactors: CBX1 CBX3 CBX5 CDC34 CDCA4 CEBPB CHAF1A CHD3 ESR1 FES HDAC10 HTRA2 IRF1 IRF7 LYN MAGEA2 MAGEA2B MAGEA3 MAGEA6 MAGED1 MYB NDNL2 NR3C1 NR4A1 NR4A3 PFDN5 PPP4C RNF4 SENP7 SERTAD1 SERTAD2 SETDB1 SIN3A SKI SMARCAD1 SPG7 STAT3 TRIM24 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2H UBE2I UBE2L3 UBE2N UBE2U VHL VIM YWHAQ ZNF10 ZNF133 ZNF140 ZNF197 ZNF354A ZNF382 ZNF420 ZNF496 ZNF689 ZNF74
Entrez ID		7625	10155
HPRD ID		01928	03445
Ensembl ID		ENSG00000185252	ENSG00000130726
Uniprot IDs		A8K5P3 Q05BG0 Q16587	Q13263
PDB IDs			1FP0 2RO1 2YVR
Enriched GO Terms of Interacting Partners?		Regulation Of Viral Process Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Stem Cell Development Negative Regulation Of DNA Demethylation Transcription, RNA-templated Stem Cell Differentiation Convergent Extension Involved In Axis Elongation Regulation Of Genetic Imprinting DNA Methylation Involved In Embryo Development DNA Repair Convergent Extension Negative Regulation Of Viral Release From Host Cell Cellular Response To DNA Damage Stimulus Transcription From RNA Polymerase II Promoter Regulation Of Viral Release From Host Cell DNA Metabolic Process Protein Sumoylation Embryonic Placenta Morphogenesis 7-methylguanosine MRNA Capping PiRNA Metabolic Process Axis Elongation Positive Regulation Of RNA Splicing 7-methylguanosine RNA Capping Positive Regulation Of DNA Repair Positive Regulation Of Transcription Factor Import Into Nucleus Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Viral Transcription Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Positive Regulation Of Gene Expression Epithelial To Mesenchymal Transition Positive Regulation Of Cellular Biosynthetic Process DNA Methylation Transcription Elongation From RNA Polymerase II Promoter Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus Somatic Stem Cell Maintenance Regulation Of Viral Transcription Cell Development Positive Regulation Of Viral Process Negative Regulation Of Viral Process Embryo Implantation DNA-templated Transcription, Elongation DNA Modification Regulation Of Transcription Factor Import Into Nucleus Nucleotide-excision Repair Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of DNA Metabolic Process Regulation Of RNA Splicing	Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Protein K48-linked Ubiquitination RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Macromolecule Biosynthetic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Protein Polyubiquitination Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Protein Catabolic Process Cellular Metabolic Process Regulation Of Cellular Process Cellular Protein Catabolic Process Positive Regulation Of Metabolic Process Protein Ubiquitination Biosynthetic Process Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Cellular Macromolecule Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process
Tagcloud ?		22q11 acgh boy counseling crkl dgs digeorge duplicated duplication duplications encompasses excluding illustrates kind lcr22 microdeletions microduplication microduplications mlpa pcqap pik4ca sharing snap29 tbx1 tdr urogenital vcfs velocardiofacial velopharyngeal	accumulates aging becoming damaged depletion genomes il6 il8 ink4a insults kap1 knocked krab limits mediating mixture ois oncogene partially pathologies prevented profound reinforcing sasp secrete secretory senescence termed undergo
Tagcloud (Difference) ?		22q11 acgh boy counseling crkl dgs digeorge duplicated duplication duplications encompasses excluding illustrates kind lcr22 microdeletions microduplication microduplications mlpa pcqap pik4ca sharing snap29 tbx1 tdr urogenital vcfs velocardiofacial velopharyngeal	accumulates aging becoming damaged depletion genomes il6 il8 ink4a insults kap1 knocked krab limits mediating mixture ois oncogene partially pathologies prevented profound reinforcing sasp secrete secretory senescence termed undergo
Tagcloud (Intersection) ?