ZNF32 and ULK2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ZNF32	ULK2
Description		zinc finger protein 32	unc-51 like autophagy activating kinase 2
Image
GO Annotations	Cellular Component	Nucleus	Phagophore Assembly Site Cytoplasm Autophagosome Cytosol Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Phagophore Assembly Site Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Autophagosome Assembly Mitophagy Autophagy Signal Transduction Nervous System Development Axonogenesis Axon Guidance Intracellular Protein Localization Regulation Of Autophagy Piecemeal Microautophagy Of The Nucleus Response To Starvation Protein Autophosphorylation Collateral Sprouting Negative Regulation Of Collateral Sprouting Axon Extension Reticulophagy Somatic Sensory System Development
Pathways
Drugs			Fostamatinib
Diseases
GWAS		Coronary artery disease ( 32469254)
Interacting Genes		12 interacting genes: CARD10 CCDC125 GOLGA6L9 INCA1 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-7 KRTAP10-8 NOTCH2NLA POT1 ULK2	15 interacting genes: ATG14 DIXDC1 DUXAP9 EEF1B2 GABARAP GABARAPL2 LNX1 LUC7L2 NASP POLA2 SETDB1 SQSTM1 SYNGAP1 TNPO1 ZNF32
Entrez ID		7580	9706
HPRD ID		01924	10556
Ensembl ID		ENSG00000169740	ENSG00000083290
Uniprot IDs		P17041	Q8IYT8
PDB IDs		2EPC 2EPT 2EPU 2YTA 2YTB	6QAT 6QAU 6QAV 6YID
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament	Mitophagy Autophagosome Autophagy Of Mitochondrion Response To Mitochondrial Depolarisation Macroautophagy Autophagosome Maturation Autophagosome Membrane Protein Transport Cellular Response To Nitrogen Starvation Intracellular Protein Localization Establishment Of Protein Localization Phosphatidylethanolamine Binding Autophagosome Assembly Regulation Of Protein Complex Stability GABA Receptor Binding Autophagosome Organization Autophagy Protein Import Into Nucleus Import Into Nucleus Protein Localization To Organelle Establishment Of Protein Localization To Organelle Protein-containing Complex Disassembly Phagophore Assembly Site Vacuole Organization Protein Localization To Nucleus Cellular Response To Starvation Beta-tubulin Binding Regulation Of Ras Protein Signal Transduction Protein Targeting Sperm Midpiece Extrinsic Component Of Phagophore Assembly Site Membrane Protein Targeting To Vacuole Response To Starvation Intracellular Protein Transport Nuclear Transport Nucleocytoplasmic Transport Synapse Organization Establishment Of Protein Localization To Vacuole Cellular Response To Nutrient Levels Brown Fat Cell Proliferation Amphisome Extrinsic Component Of Omegasome Membrane Regulation Of Small GTPase Mediated Signal Transduction Ubiquitin Protein Ligase Binding Positive Regulation Of Protein K48-linked Ubiquitination Protein Localization To Vacuole Eukaryotic Translation Elongation Factor 1 Complex Organelle Assembly Histone H3K9 Trimethyltransferase Activity
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