TMEM50B and NCR1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM50B	NCR1
Description		transmembrane protein 50B	natural cytotoxicity triggering receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane	Plasma Membrane Membrane SWI/SNF Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway	Immune Response-regulating Signaling Pathway Cellular Defense Response Signal Transduction Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Cytotoxicity
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Crohn's disease ( 23128233) Educational attainment ( 25201988)	Blood protein levels ( 30072576) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494)
Interacting Genes		21 interacting genes: AMIGO1 BCL2L1 CLRN1 CREB3L1 EDA FAM209A FXYD3 GPR152 GPX8 HLA-DPA1 LEPROTL1 LHFPL5 NCR1 SCN3B SLC10A6 SLC16A13 SLC35H1 TMEM14B TMEM52B TMEM88 TMX2	8 interacting genes: ADAM33 APP CD247 CD59 FCER1G RHOU TMEM229B TMEM50B
Entrez ID		757	9437
HPRD ID		10747	05167
Ensembl ID		ENSG00000142188	ENSG00000189430
Uniprot IDs		F8WDH1 P56557 Q2V8N0	A0A0A0MQZ0 A0A0A0MR94 A0A0A0MTU0 O76036
PDB IDs			1OLL 1P6F 6IAP
Enriched GO Terms of Interacting Partners?		Membrane Mitochondrial Membrane	Fc-gamma Receptor III Complex Myeloid Leukocyte Activation Plasma Membrane Protein Complex Positive Regulation Of Protein Localization To Cell Surface Leukocyte Activation Cell Activation Fc-gamma Receptor Signaling Pathway Regulation Of Protein Localization To Cell Surface Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Macrophage Activation Amylin Binding External Side Of Plasma Membrane Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Localization Fc Receptor Signaling Pathway Tertiary Granule Membrane IgE Receptor Activity Acetylcholine Receptor Activator Activity Positive Regulation Of Immune System Process PTB Domain Binding Immune Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Membrane Regulation Of Immune Response Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Response To Bacterium Endocytosis Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Vesicle-mediated Transport Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Protein Localization Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Immune Effector Process Immune System Process Activation Of Immune Response Gamma-delta T Cell Receptor Complex Negative Regulation Of Activation Of Membrane Attack Complex Positive Regulation Of Type I Hypersensitivity Negative Regulation Of Mast Cell Apoptotic Process Serotonin Secretion By Platelet
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