LDLRAD4 and GET3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LDLRAD4	GET3
Description		low density lipoprotein receptor class A domain containing 4	guided entry of tail-anchored proteins factor 3, ATPase
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endosome Membrane Early Endosome Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane GET Complex Extracellular Exosome
	Molecular Function	Protein Binding R-SMAD Binding	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Membrane Insertase Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Signal Transduction Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of SMAD Protein Signal Transduction	Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Protein Insertion Into ER Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways			Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs			ATP
Diseases
GWAS		Adverse response to drug ( 30420678) Depressive symptom improvement ( 30468137) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (functional units) ( 27694959) Macular thickness ( 30535121) Plateletcrit ( 32888494) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		4 interacting genes: GET3 NEDD4 SGTA ZDHHC22	38 interacting genes: AGR2 APLN ASPH CACNA1A CREB3L4 EMSY FAM209A FKBP7 GOLM1 GPX7 GPX8 HILPDA IGFBP6 KCNE4 KCNE5 LDLRAD4 PDIA6 PEX14 PFDN1 PGRMC1 PGRMC2 PRB3 PRR4 RHEX SEC61A1 SEC61B SMIM19 SPP1 STATH SYPL2 TK1 TMEM154 TMEM51 TMX1 TTR VAMP2 VWC2 WFDC3
Entrez ID		753	439
HPRD ID		07358	03555
Ensembl ID		ENSG00000168675	ENSG00000198356
Uniprot IDs		A0A7I2V575 A8K6A9 O15165	O43681
PDB IDs			6SO5 8CQZ 8CR1 8CR2
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization To Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane Protein Targeting Protein Insertion Into ER Membrane Establishment Of Protein Localization Cellular Localization Protein Insertion Into Membrane Protein Targeting To Membrane Localization Within Membrane Formation Of Structure Involved In A Symbiotic Process Channel Inhibitor Activity TRC Complex GET Complex Phosphothreonine Residue Binding Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Positive Regulation Of Protein Catabolic Process BAT3 Complex Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway Phosphoserine Residue Binding Beta-2 Adrenergic Receptor Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of ERAD Pathway Sodium Channel Inhibitor Activity Establishment Of Protein Localization To Organelle Potassium Channel Inhibitor Activity Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Potassium Ion Export Across Plasma Membrane Progesterone Receptor Signaling Pathway Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Endocardial Cushion Development Negative Regulation Of Sodium Ion Transport Membrane Insertase Activity Proline-rich Region Binding Receptor Catabolic Process RNA Polymerase Binding Positive Regulation Of ERAD Pathway Protein Palmitoylation Palmitoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Negative Regulation Of Potassium Ion Transmembrane Transport Apicolateral Plasma Membrane Viral Budding Regulation Of ERAD Pathway Antigen Processing And Presentation Of Endogenous Antigen Postsynaptic Cytosol Ionotropic Glutamate Receptor Binding Protein Targeting To Lysosome Negative Regulation Of Potassium Ion Transport	Extracellular Region Endoplasmic Reticulum Lumen Intracellular Protein Transmembrane Transport Body Fluid Secretion Sec61 Translocon Complex SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Post-translational Protein Targeting To Membrane, Translocation Endoplasmic Reticulum Extracellular Space Regulation Of Body Fluid Levels Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization Ventricular Cardiac Muscle Cell Membrane Repolarization Mucus Secretion Potassium Ion Export Across Plasma Membrane Protein Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Voltage-gated Potassium Channel Complex Regulation Of Heart Contraction Amyloid-beta Binding Glutathione Peroxidase Activity Protein Disulfide Isomerase Activity Membrane Repolarization During Cardiac Muscle Cell Action Potential Delayed Rectifier Potassium Channel Activity Membrane Repolarization During Action Potential Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Protein Binding Regulation Of System Process Protein-disulfide Reductase Activity
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