AQP5 and GLRX

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		AQP5	GLRX
Name		aquaporin 5	glutaredoxin
Structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Microvillus Basal Plasma Membrane Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Extracellular Exosome	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Water Channel Activity Channel Activity Identical Protein Binding	Protein Binding Disulfide Oxidoreductase Activity Glutathione Disulfide Oxidoreductase Activity Sodium Channel Regulator Activity
	Biological Process	Water Transport Carbon Dioxide Transport Pancreatic Juice Secretion Odontogenesis Saliva Secretion Camera-type Eye Morphogenesis Protein Homotetramerization Transmembrane Transport Cellular Hypotonic Response	Nucleobase-containing Small Molecule Interconversion Positive Regulation Of Membrane Potential
Pathways		Passive transport by Aquaporins	Interconversion of nucleotide di- and triphosphates
Drugs		None	Glutathione
GWAS		Allergic rhinitis ( 30013184 ) Asthma ( 32296059 )	hemolysis of donated blood (oxidative) ( 34014839 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Metabolite levels ( 23823483 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 )
Novel Interactors		1 novel interactors: TUBA1C	None recorded
Interacting Genes		8 interacting genes: CREB3 GLRX HNRNPK KRT31 KRT40 MDFI NOTCH2NLA WNT2	8 interacting genes: AQP5 CASP3 GOT2 MAP3K5 MMP23B NFIC PTPN1 TRIM62
Entrez ID		362	2745
HPRD ID		02706	02707
Ensembl ID		ENSG00000161798	ENSG00000173221
Uniprot IDs		P55064	P35754
PDB IDs		3D9S 5C5X 5DYE 7STC	1B4Q 1JHB 4RQR
GO Terms Enriched among Interactors		Structural Molecule Activity Glutathione Disulfide Oxidoreductase Activity Structural Constituent Of Skin Epidermis Tissue Morphogenesis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Positive Regulation Of Deacetylase Activity Structural Constituent Of Cytoskeleton	Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Reactive Nitrogen Species Cellular Response To Osmotic Stress Cellular Response To Chemical Stress Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Osmotic Stress Odontogenesis Response To Hydrogen Peroxide Phospholipase A2 Activator Activity L-glutamate Catabolic Process To Aspartate L-aspartate:2-oxoglutarate Aminotransferase Activity Aspartate Biosynthetic Process Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of JNK Cascade Pancreatic Juice Secretion Positive Regulation Of Programmed Cell Death Anterior Neural Tube Closure Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Apoptotic Process Response To Tumor Necrosis Factor Cellular Response To Staurosporine Neuron Apoptotic Process Luteolysis Glial Cell Apoptotic Process Response To Reactive Oxygen Species L-aspartate Catabolic Process Trans-4-hydroxy-L-proline Catabolic Process Kynurenine-oxoglutarate Transaminase Activity Protein Kinase Complex IRE1-TRAF2-ASK1 Complex Regulation Of JNK Cascade Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Insulin Receptor Recycling Positive Regulation Of Antifungal Innate Immune Response Saliva Secretion Response To Anesthetic Intrinsic Apoptotic Signaling Pathway Sorting Endosome Endoplasmic Reticulum Death-inducing Signaling Complex Aspartate Metabolic Process Cellular Response To Stress Oxaloacetate Metabolic Process L-glutamate Catabolic Process Malate-aspartate Shuttle Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of IRE1-mediated Unfolded Protein Response Mitochondrial Crista Positive Regulation Of Pyroptotic Inflammatory Response