NELFA and NELFB

Number of citations of the paper that reports this interaction (PMID 12612062)
52

Data Source:
BioGRID (pull down, affinity chromatography technology)

		NELFA	NELFB
Gene Name		negative elongation factor complex member A	negative elongation factor complex member B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm NELF Complex	Nucleoplasm Cytoplasm NELF Complex
	Molecular Function	Chromatin Binding Protein Binding	Protein Binding
	Biological Process	Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Multicellular Organismal Development Gene Expression Viral Process Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription	Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Transcription
Pathways		Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation	Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: APP NELFB NELFCD POLR2A PRR22 SIAH1	12 interactors: BRCA1 CEBPE DENR ESR1 FOS HSPA9 JUN KHDRBS3 MAPK6 MGST1 NELFA NELFE
Entrez ID		7469	25920
HPRD ID		12080	10845
Ensembl ID		ENSG00000185049	ENSG00000188986
Uniprot IDs		B3KSP0 Q9H3P2	Q8WX92
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Viral Transcription Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Elongation Regulation Of Viral Process Neuron Apoptotic Process Neuron Death Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Viral Process Regulation Of Gene Expression Transcription, RNA-templated Synaptic Growth At Neuromuscular Junction Transcription From RNA Polymerase II Promoter Collateral Sprouting In Absence Of Injury Positive Regulation Of Cellular Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition RNA Metabolic Process Neuron Remodeling Positive Regulation Of Metabolic Process Gene Expression Axon Guidance MRNA Processing Regulation Of Metabolic Process Posttranscriptional Regulation Of Gene Expression Cellular Copper Ion Homeostasis Cell Development Regulation Of Transcription, DNA-templated Copper Ion Homeostasis Suckling Behavior Axonogenesis Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process MRNA Metabolic Process Protein Destabilization Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of RNA Metabolic Process Axon Development RNA Processing Cell Morphogenesis Involved In Neuron Differentiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Chemotaxis Neuron Maturation MRNA Polyadenylation	Positive Regulation Of Viral Transcription Response To Lipid Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Viral Transcription Biosynthetic Process Positive Regulation Of Viral Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Response To Lipopolysaccharide Negative Regulation Of DNA-templated Transcription, Elongation Response To Molecule Of Bacterial Origin Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Regulation Of Viral Process Response To Bacterium Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription Elongation From RNA Polymerase II Promoter MAPK Cascade Nitrogen Compound Metabolic Process Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription, DNA-templated Cellular Response To Calcium Ion Negative Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of RNA Biosynthetic Process Response To Other Organism Toll-like Receptor 5 Signaling Pathway Signal Transduction By Phosphorylation RNA Metabolic Process Toll-like Receptor 10 Signaling Pathway Regulation Of RNA Metabolic Process SMAD Protein Signal Transduction Response To Biotic Stimulus Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Nucleobase-containing Compound Metabolic Process Toll-like Receptor 9 Signaling Pathway Transcription Elongation From RNA Polymerase II Promoter
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