ENDOD1

Description		endonuclease domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Membrane Extracellular Exosome
	Molecular Function	Nucleic Acid Binding Nuclease Activity Endonuclease Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Immune System Process Innate Immune Response
Pathways		Platelet degranulation
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean platelet volume ( 27863252 32888494) Platelet count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels x loop diuretics use interaction ( 31806883)
Novel Interacting Genes		1 novel interacting genes: MRE11
Interacting Genes		1 interacting genes: VSNL1
Entrez ID		23052
HPRD ID		13819
Ensembl ID		ENSG00000149218
Uniprot IDs		O94919
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitochondrial Double-strand Break Repair Via Homologous Recombination Meiotic DNA Double-strand Break Formation Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Mre11 Complex BRCA1-C Complex Single-stranded DNA Endodeoxyribonuclease Activity 3'-5'-DNA Exonuclease Activity Regulation Of Mitotic Recombination Chromosomal Region Telomeric 3' Overhang Formation R-loop Processing DNA Strand Resection Involved In Replication Fork Processing 3'-5' Exonuclease Activity Mitotic Intra-S DNA Damage Checkpoint Signaling Replication Fork DNA Endonuclease Activity Telomere Maintenance Via Telomere Lengthening Homologous Chromosome Pairing At Meiosis RNA-templated DNA Biosynthetic Process DNA Strand Elongation Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Telomere Maintenance Via Telomerase DNA Double-strand Break Processing Reciprocal Meiotic Recombination Negative Regulation Of DNA Repair Mitotic G2 DNA Damage Checkpoint Signaling Sister Chromatid Cohesion Homologous Recombination DNA Helicase Activity Negative Regulation Of Double-strand Break Repair Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Exonuclease Activity Mitotic G2/M Transition Checkpoint Chromosome Organization Involved In Meiotic Cell Cycle Double-strand Break Repair Via Nonhomologous End Joining Manganese Ion Binding Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Telomere Maintenance Meiosis I Cell Cycle Process Mitotic DNA Integrity Checkpoint Signaling Endonuclease Activity Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of Protein Secretion Negative Regulation Of Hormone Secretion Positive Regulation Of Exocytosis Positive Regulation Of Insulin Secretion
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