VEGFB and UCP3

Data Source: HiPPIP (Novel)

		VEGFB	UCP3
Name		vascular endothelial growth factor B	uncoupling protein 3
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen	Mitochondrion Mitochondrial Inner Membrane Membrane
	Molecular Function	Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity Identical Protein Binding Vascular Endothelial Growth Factor Receptor 1 Binding Receptor Ligand Activity	Protein Binding Proton Transmembrane Transporter Activity Calcium Ion Transmembrane Transporter Activity Oxidative Phosphorylation Uncoupler Activity
	Biological Process	Response To Hypoxia Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Protein O-linked Glycosylation Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Vascular Wound Healing Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Negative Regulation Of Neuron Apoptotic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cardiac Muscle Contraction Positive Regulation Of Mast Cell Chemotaxis Coronary Vasculature Development Positive Regulation Of ERK1 And ERK2 Cascade	Response To Superoxide Response To Hypoxia Lipid Metabolic Process Fatty Acid Metabolic Process Response To Nutrient Respiratory Gaseous Exchange By Respiratory System Response To Cold Response To Activity Response To Insulin Cellular Response To Hormone Stimulus Response To Steroid Hormone Response To Glucocorticoid Transmembrane Transport Lipid Hydroperoxide Transport Response To Fenofibrate Proton Transmembrane Transport Mitochondrial Transmembrane Transport Adaptive Thermogenesis
Pathways		Platelet degranulation VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization	The fatty acid cycling model
Drugs		Aflibercept	None
Diseases		Gastric cancer	None
GWAS		A body shape index ( 34021172 ) Apolipoprotein A1 levels ( 32203549 ) Crohn's disease ( 28067908 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Fruit consumption ( 32066663 ) HDL cholesterol levels ( 32203549 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Red blood cell count ( 32888494 ) Triglyceride levels ( 32203549 ) Triglycerides ( 30275531 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist-to-hip ratio adjusted for body mass index ( 25673412 )	No GWAS studies recorded
Novel Interactors		5 novel interactors: FOSL1 SF1 TFB1M UCP2 UCP3	1 novel interactors: VEGFB
Interacting Genes		6 interacting genes: ADRB2 FLT1 KLHL12 NRP1 TNXB VEGFA	6 interacting genes: HNRNPD RC3H1 YWHAB YWHAG YWHAQ YWHAZ
Entrez ID		7423	7352
HPRD ID		03237	03623
Ensembl ID		ENSG00000173511	ENSG00000175564
Uniprot IDs		P49765 Q7LAP4	A0A0S2Z4G5 P55916
PDB IDs		2C7W 2VWE 2XAC 6TKK	Not available
GO Terms Enriched among Interactors		Adaptive Thermogenesis Vascular Endothelial Growth Factor Signaling Pathway VEGF-activated Neuropilin Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Sprouting Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Cold Neuropilin Signaling Pathway Oxidative Phosphorylation Uncoupler Activity Response To Superoxide Positive Regulation Of Axon Extension Involved In Axon Guidance Vascular Endothelial Growth Factor Receptor Activity Response To Oxygen Radical Coronary Artery Morphogenesis Coronary Vasculature Morphogenesis Endothelial Cell Chemotaxis Regulation Of MAPK Cascade Positive Regulation Of Cold-induced Thermogenesis Blood Vessel Morphogenesis Commissural Neuron Axon Guidance Motor Neuron Migration Chemotaxis Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Axon Extension Involved In Axon Guidance Locomotion Mitochondrial Transmembrane Transport Retinal Ganglion Cell Axon Guidance Regulation Of Cold-induced Thermogenesis Response To Temperature Stimulus Regulation Of Endothelial Cell Proliferation Proton Transmembrane Transporter Activity Cell Migration Involved In Sprouting Angiogenesis Heparin Binding Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Population Proliferation Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Angiogenesis Positive Regulation Of Vasculature Development Branching Involved In Blood Vessel Morphogenesis Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Receptor Complex Mitochondrial Transport Platelet-derived Growth Factor Receptor Signaling Pathway Blood Vessel Endothelial Cell Migration Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Cell Chemotaxis Positive Regulation Of Axon Extension Growth Factor Binding	Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Protein Targeting Protein Sequestering Activity Protein Domain Specific Binding Negative Regulation Of Macromolecule Metabolic Process Phosphoserine Residue Binding Negative Regulation Of Metabolic Process Focal Adhesion 3'-UTR-mediated MRNA Destabilization Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Immune Response Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Protein Localization To Nucleus Cellular Response To Glucose Starvation Identical Protein Binding TORC1 Signaling Negative Regulation Of TORC1 Signaling Regulation Of Macromolecule Metabolic Process Hepatocyte Dedifferentiation Cellular Response To Putrescine Negative Regulation Of Adaptive Immune Response TOR Signaling Negative Regulation Of Gene Expression Negative Regulation Of TOR Signaling Regulation Of Metabolic Process MRNA Destabilization Regulation Of TORC1 Signaling RNA Destabilization Melanosome Circadian Regulation Of Translation Synaptic Target Recognition CCR4-NOT Complex Binding Negative Regulation Of Germinal Center Formation Positive Regulation Of MRNA Catabolic Process Establishment Of Protein Localization Negative Regulation Of Immune System Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Histone Deacetylase Binding Regulation Of Biological Quality Animal Organ Development Vascular Endothelial Growth Factor Receptor 1 Binding Signal Transduction Negative Regulation Of T Cell Activation Protein Kinase C Inhibitor Activity Transmembrane Transporter Binding Positive Regulation Of MRNA Metabolic Process