UCP3 and RC3H1

Number of citations of the paper that reports this interaction (PubMedID 32491174)
86

Data Source:
BioGRID (unspecified method)

		UCP3	RC3H1
Description		uncoupling protein 3	ring finger and CCCH-type domains 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane	P-body Cytoplasm Cytoplasmic Stress Granule
	Molecular Function	Protein Binding Proton Transmembrane Transporter Activity Calcium Ion Transmembrane Transporter Activity Oxidative Phosphorylation Uncoupler Activity	RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity MiRNA Binding RNA Stem-loop Binding Metal Ion Binding Ubiquitin Protein Ligase Activity CCR4-NOT Complex Binding
	Biological Process	Response To Superoxide Response To Hypoxia Lipid Metabolic Process Fatty Acid Metabolic Process Response To Nutrient Respiratory Gaseous Exchange By Respiratory System Response To Cold Response To Activity Response To Insulin Cellular Response To Hormone Stimulus Response To Steroid Hormone Response To Glucocorticoid Transmembrane Transport Lipid Hydroperoxide Transport Response To Fenofibrate Proton Transmembrane Transport Mitochondrial Transmembrane Transport Adaptive Thermogenesis	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein Polyubiquitination Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process B Cell Homeostasis Regulation Of Germinal Center Formation Negative Regulation Of Germinal Center Formation Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Post-transcriptional Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of B Cell Proliferation P-body Assembly T Cell Proliferation T Cell Homeostasis Regulation Of MRNA Stability Negative Regulation Of T-helper Cell Differentiation Negative Regulation Of Activated T Cell Proliferation Lymph Node Development Spleen Development T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization T Follicular Helper Cell Differentiation Cellular Response To Interleukin-1 Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of T-helper 17 Cell Differentiation Regulation Of MiRNA Metabolic Process
Pathways		The fatty acid cycling model
Drugs
Diseases
GWAS			Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		6 interacting genes: HNRNPD RC3H1 YWHAB YWHAG YWHAQ YWHAZ	14 interacting genes: ICOS TNF TNFRSF4 UBE2A UBE2B UBE2D2 UBE2F UBE2G1 UBE2G2 UBE2L3 UBE2N UBE2V1 UBE2V2 UCP3
Entrez ID		7352	149041
HPRD ID		03623	13913
Ensembl ID		ENSG00000175564	ENSG00000135870
Uniprot IDs		A0A0S2Z4G5 P55916	B7ZMB3 B9EGU6 Q5TC82
PDB IDs			3X1O 4QIK 4QIL 4ULW 4YWQ 8RHS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Protein Targeting Protein Sequestering Activity Protein Domain Specific Binding Negative Regulation Of Macromolecule Metabolic Process Phosphoserine Residue Binding Negative Regulation Of Metabolic Process Focal Adhesion 3'-UTR-mediated MRNA Destabilization Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Immune Response Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Protein Localization To Nucleus Cellular Response To Glucose Starvation Identical Protein Binding TORC1 Signaling Negative Regulation Of TORC1 Signaling Regulation Of Macromolecule Metabolic Process Hepatocyte Dedifferentiation Cellular Response To Putrescine Negative Regulation Of Adaptive Immune Response TOR Signaling Negative Regulation Of Gene Expression Negative Regulation Of TOR Signaling Regulation Of Metabolic Process MRNA Destabilization Regulation Of TORC1 Signaling RNA Destabilization Melanosome Circadian Regulation Of Translation Synaptic Target Recognition CCR4-NOT Complex Binding Negative Regulation Of Germinal Center Formation Positive Regulation Of MRNA Catabolic Process Establishment Of Protein Localization Negative Regulation Of Immune System Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Histone Deacetylase Binding Regulation Of Biological Quality Animal Organ Development Vascular Endothelial Growth Factor Receptor 1 Binding Signal Transduction Negative Regulation Of T Cell Activation Protein Kinase C Inhibitor Activity Transmembrane Transporter Binding Positive Regulation Of MRNA Metabolic Process	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Postreplication Repair Protein Ubiquitination Ubiquitin-protein Transferase Activity UBC13-MMS2 Complex Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Complex Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Protein K63-linked Ubiquitination Protein Modification Process Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Polyubiquitination Macromolecule Catabolic Process Error-free Postreplication DNA Repair Proteolysis Regulation Of Post-translational Protein Modification Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Polyubiquitination Ubiquitin Protein Ligase Binding Positive Regulation Of Post-translational Protein Modification ATP Binding Protein K11-linked Ubiquitination Protein Catabolic Process Regulation Of Protein Modification Process HULC Complex Positive Regulation Of Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Protein Ubiquitination Nucleotide Binding Transferase Activity DNA Damage Response Response To Stress Ubiquitin-protein Transferase Activator Activity Regulation Of DNA Metabolic Process DNA Repair Catabolic Process Positive Regulation Of DNA Metabolic Process Ubiquitin Ligase Complex Cellular Response To Stress Macromolecule Metabolic Process Response To Glucocorticoid
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