UCP3 and VEGFB

Data Source: HiPPIP (Novel)

		UCP3	VEGFB
Name		uncoupling protein 3	vascular endothelial growth factor B
Structure		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen
	Molecular Function	Protein Binding Proton Transmembrane Transporter Activity Calcium Ion Transmembrane Transporter Activity Oxidative Phosphorylation Uncoupler Activity	Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity Identical Protein Binding Vascular Endothelial Growth Factor Receptor 1 Binding Receptor Ligand Activity
	Biological Process	Response To Superoxide Response To Hypoxia Lipid Metabolic Process Fatty Acid Metabolic Process Response To Nutrient Respiratory Gaseous Exchange By Respiratory System Response To Cold Response To Activity Response To Insulin Cellular Response To Hormone Stimulus Response To Steroid Hormone Response To Glucocorticoid Transmembrane Transport Lipid Hydroperoxide Transport Response To Fenofibrate Proton Transmembrane Transport Mitochondrial Transmembrane Transport Adaptive Thermogenesis	Response To Hypoxia Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Protein O-linked Glycosylation Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Vascular Wound Healing Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Negative Regulation Of Neuron Apoptotic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cardiac Muscle Contraction Positive Regulation Of Mast Cell Chemotaxis Coronary Vasculature Development Positive Regulation Of ERK1 And ERK2 Cascade
Pathways		The fatty acid cycling model	Platelet degranulation VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization
Drugs		None	Aflibercept
Diseases		None	Gastric cancer
GWAS		No GWAS studies recorded	A body shape index ( 34021172 ) Apolipoprotein A1 levels ( 32203549 ) Crohn's disease ( 28067908 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Fruit consumption ( 32066663 ) HDL cholesterol levels ( 32203549 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Red blood cell count ( 32888494 ) Triglyceride levels ( 32203549 ) Triglycerides ( 30275531 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist-to-hip ratio adjusted for body mass index ( 25673412 )
Novel Interactors		1 novel interactors: VEGFB	5 novel interactors: FOSL1 SF1 TFB1M UCP2 UCP3
Interacting Genes		6 interacting genes: HNRNPD RC3H1 YWHAB YWHAG YWHAQ YWHAZ	6 interacting genes: ADRB2 FLT1 KLHL12 NRP1 TNXB VEGFA
Entrez ID		7352	7423
HPRD ID		03623	03237
Ensembl ID		ENSG00000175564	ENSG00000173511
Uniprot IDs		A0A0S2Z4G5 P55916	P49765 Q7LAP4
PDB IDs		Not available	2C7W 2VWE 2XAC 6TKK
GO Terms Enriched among Interactors		Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Protein Targeting Protein Sequestering Activity Protein Domain Specific Binding Negative Regulation Of Macromolecule Metabolic Process Phosphoserine Residue Binding Negative Regulation Of Metabolic Process Focal Adhesion 3'-UTR-mediated MRNA Destabilization Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Immune Response Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Protein Localization To Nucleus Cellular Response To Glucose Starvation Identical Protein Binding TORC1 Signaling Negative Regulation Of TORC1 Signaling Regulation Of Macromolecule Metabolic Process Hepatocyte Dedifferentiation Cellular Response To Putrescine Negative Regulation Of Adaptive Immune Response TOR Signaling Negative Regulation Of Gene Expression Negative Regulation Of TOR Signaling Regulation Of Metabolic Process MRNA Destabilization Regulation Of TORC1 Signaling RNA Destabilization Melanosome Circadian Regulation Of Translation Synaptic Target Recognition CCR4-NOT Complex Binding Negative Regulation Of Germinal Center Formation Positive Regulation Of MRNA Catabolic Process Establishment Of Protein Localization Negative Regulation Of Immune System Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Histone Deacetylase Binding Regulation Of Biological Quality Animal Organ Development Vascular Endothelial Growth Factor Receptor 1 Binding Signal Transduction Negative Regulation Of T Cell Activation Protein Kinase C Inhibitor Activity Transmembrane Transporter Binding Positive Regulation Of MRNA Metabolic Process	Adaptive Thermogenesis Vascular Endothelial Growth Factor Signaling Pathway VEGF-activated Neuropilin Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Sprouting Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Cold Neuropilin Signaling Pathway Oxidative Phosphorylation Uncoupler Activity Response To Superoxide Positive Regulation Of Axon Extension Involved In Axon Guidance Vascular Endothelial Growth Factor Receptor Activity Response To Oxygen Radical Coronary Artery Morphogenesis Coronary Vasculature Morphogenesis Endothelial Cell Chemotaxis Regulation Of MAPK Cascade Positive Regulation Of Cold-induced Thermogenesis Blood Vessel Morphogenesis Commissural Neuron Axon Guidance Motor Neuron Migration Chemotaxis Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Axon Extension Involved In Axon Guidance Locomotion Mitochondrial Transmembrane Transport Retinal Ganglion Cell Axon Guidance Regulation Of Cold-induced Thermogenesis Response To Temperature Stimulus Regulation Of Endothelial Cell Proliferation Proton Transmembrane Transporter Activity Cell Migration Involved In Sprouting Angiogenesis Heparin Binding Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Population Proliferation Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Angiogenesis Positive Regulation Of Vasculature Development Branching Involved In Blood Vessel Morphogenesis Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Receptor Complex Mitochondrial Transport Platelet-derived Growth Factor Receptor Signaling Pathway Blood Vessel Endothelial Cell Migration Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Cell Chemotaxis Positive Regulation Of Axon Extension Growth Factor Binding