ATXN7L3 and UCHL3

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ATXN7L3	UCHL3
Gene Name		ataxin 7-like 3	ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Image
Gene Ontology Annotations	Cellular Component	SAGA Complex DUBm Complex	Nucleus Nucleoplasm Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity	Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity Ubiquitin Binding
	Biological Process	Chromatin Organization Transcription, DNA-templated Histone Deubiquitination Positive Regulation Of Transcription, DNA-templated	Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS			Diabetic retinopathy ( 23562823)
Protein-Protein Interactions		7 interactors: HIST2H2AC HIST2H2BE PICK1 SECISBP2 SERTAD1 UCHL3 USP6	17 interactors: ATXN7L3 CDH1 HMP19 LONRF1 NEDD8 PJA1 PLA2G2A POGK TRIM27 TRIM54 TRIM55 TRIM63 UBC UBE2S USP15 USP21 USP28
Entrez ID		56970	7347
HPRD ID		12507	04367
Ensembl ID		ENSG00000087152	ENSG00000118939
Uniprot IDs		Q14CW9	P15374
PDB IDs		2KKT	1UCH 1XD3
Enriched GO Terms of Interacting Partners?			Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Catabolic Process Protein Modification By Small Protein Conjugation Proteolysis Histone Deubiquitination Protein Deubiquitination Protein Modification By Small Protein Removal Cellular Protein Modification Process Protein Ubiquitination Protein Polyubiquitination Regulation Of Protein Catabolic Process Activation Of Anaphase-promoting Complex Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Cellular Protein Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Ubiquitination Protein K11-linked Ubiquitination Transforming Growth Factor Beta Receptor Signaling Pathway DNA Damage Checkpoint Regulation Of Cellular Protein Metabolic Process Protein K63-linked Ubiquitination Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process Cell Cycle Checkpoint Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cellular Process Negative Regulation Of Transferase Activity Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Free Ubiquitin Chain Polymerization Negative Regulation Of Interleukin-2 Secretion Histone H2B Conserved C-terminal Lysine Deubiquitination Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		acetyltransferase activators coactivators cofactor cofactors counteract dense deubiquitinase deubiquitination drosophila enhancer eny2 gcn5 h2a h2b hat heterochromatin loci loosening mda metazoan module necessary pol precise staga tftc usp22 variegation	attempts c2 canine changed chemokine depends eia3 eia4 epo folding gstt3 hours hsp90 hypothetical introduced kit masitinib mast neoplastic pdia3 pro proliferative proteome selenbp1 steroid tardbp transcriptionally transcriptome tumour
Tagcloud (Difference) ?		acetyltransferase activators coactivators cofactor cofactors counteract dense deubiquitinase deubiquitination drosophila enhancer eny2 gcn5 h2a h2b hat heterochromatin loci loosening mda metazoan module necessary pol precise staga tftc usp22 variegation	attempts c2 canine changed chemokine depends eia3 eia4 epo folding gstt3 hours hsp90 hypothetical introduced kit masitinib mast neoplastic pdia3 pro proliferative proteome selenbp1 steroid tardbp transcriptionally transcriptome tumour
Tagcloud (Intersection) ?