TYR and TYRP1

Number of citations of the paper that reports this interaction (PMID 14623273)
2

Data Source:
HPRD (in vivo)

		TYR	TYRP1
Gene Name		tyrosinase	tyrosinase-related protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosome Golgi-associated Vesicle Integral Component Of Membrane Melanosome Membrane Melanosome Perinuclear Region Of Cytoplasm	Endosome Membrane Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane Melanosome Membrane Melanosome
	Molecular Function	Monophenol Monooxygenase Activity Copper Ion Binding Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Copper Ion Binding Protein Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Another Compound As One Donor, And Incorporation Of One Atom Of Oxygen Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Melanin Biosynthetic Process From Tyrosine Eye Pigment Biosynthetic Process Visual Perception Cell Proliferation Thymus Development Oxidation-reduction Process	Melanocyte Differentiation Melanosome Organization Melanin Biosynthetic Process Acetoacetic Acid Metabolic Process Oxidation-reduction Process
Pathways
Drugs		NADH Azelaic Acid Monobenzone Mimosine
Diseases
GWAS		Age-related macular degeneration ( 23326517) Blue vs. green eyes ( 17952075) Eye color ( 20585627) Freckles ( 17952075) Melanoma ( 21983787 19578364) Skin pigmentation ( 17999355) Skin sensitivity to sun ( 17952075) Sunburns ( 23548203) Tanning ( 23548203 19340012) Vitiligo ( 20410501 22561518)	Blue vs. green eyes ( 18488028) Eye color ( 23548203) Hair color ( 22556244)
Protein-Protein Interactions		1 interactors: TYRP1	2 interactors: GIPC1 TYR
Entrez ID		7299	7306
HPRD ID		06086	00283
Ensembl ID		ENSG00000077498	ENSG00000107165
Uniprot IDs		L8B082 P14679	P17643
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetoacetic Acid Metabolic Process Short-chain Fatty Acid Metabolic Process Melanin Biosynthetic Process Melanin Metabolic Process Melanosome Organization Secondary Metabolite Biosynthetic Process Pigment Granule Organization Melanocyte Differentiation Neuroepithelial Cell Differentiation Pigment Biosynthetic Process Cellular Pigmentation Developmental Pigmentation Phenol-containing Compound Metabolic Process Pigmentation Vesicle Organization Fatty Acid Metabolic Process Epithelial Cell Differentiation Monocarboxylic Acid Metabolic Process	Melanin Biosynthetic Process From Tyrosine Eye Pigment Biosynthetic Process Eye Pigmentation Tyrosine Metabolic Process Melanin Biosynthetic Process Melanin Metabolic Process Glutamate Secretion Secondary Metabolite Biosynthetic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cytokinesis Aromatic Amino Acid Family Metabolic Process Acid Secretion Regulation Of Cytokinesis Thymus Development Pigment Biosynthetic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Developmental Pigmentation Negative Regulation Of Cellular Protein Catabolic Process Endothelial Cell Migration Dicarboxylic Acid Transport Epithelial Cell Migration Phenol-containing Compound Metabolic Process Epithelium Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Catabolic Process Pigmentation Positive Regulation Of Cell Division Regulation Of Protein Stability Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Amino Acid Transport Regulation Of Synaptic Plasticity Visual Perception Sensory Perception Of Light Stimulus Ameboidal-type Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Proteasomal Protein Catabolic Process
Tagcloud ?		5b carcinogens coactivator competition cooh cos delta12 deoxy genotoxic gh hormonal indirect j2 janus pd98059 peroxisome ppar pparalpha prolactin proliferator prostaglandin reconstituted stat1 stat5b structurally supershift talk transcriptionally transducer	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3
Tagcloud (Difference) ?		5b carcinogens coactivator competition cooh cos delta12 deoxy genotoxic gh hormonal indirect j2 janus pd98059 peroxisome ppar pparalpha prolactin proliferator prostaglandin reconstituted stat1 stat5b structurally supershift talk transcriptionally transducer	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3
Tagcloud (Intersection) ?