TYK2 and SULT1A1

		TYK2	SULT1A1
Description		tyrosine kinase 2	sulfotransferase family 1A member 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Extrinsic Component Of Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Interleukin-12 Receptor Complex Receptor Complex Extracellular Exosome Interleukin-23 Receptor Complex	Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity	Aryl Sulfotransferase Activity Protein Binding Sulfotransferase Activity Transferase Activity Flavonol 3-sulfotransferase Activity Steroid Sulfotransferase Activity 3'-phosphoadenosine 5'-phosphosulfate Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Immune Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Population Proliferation Cytokine-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Cell Differentiation Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Intracellular Signal Transduction Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Alpha-beta T Cell Activation Positive Regulation Of NK T Cell Proliferation Type II Interferon-mediated Signaling Pathway Type I Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cellular Response To Virus Interleukin-10-mediated Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of T-helper 17 Type Immune Response	Ethanol Catabolic Process Catecholamine Metabolic Process Lipid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Amine Metabolic Process Flavonoid Metabolic Process Thyroid Hormone Metabolic Process Dopamine Catabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation
Pathways		Interleukin-6 signaling Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Other interleukin signaling Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Interleukin-20 family signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling Interleukin-27 signaling Interleukin-27 signaling Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Potential therapeutics for SARS Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Signaling by ALK fusions and activated point mutants Evasion by RSV of host interferon responses	Cytosolic sulfonation of small molecules Paracetamol ADME
Drugs		2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one Ruxolitinib Tofacitinib Baricitinib Fostamatinib Abrocitinib Deucravacitinib	Adenosine 3',5'-diphosphate P-Nitrophenol
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Ankylosing spondylitis ( 23749187) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) COVID-19 (critical illness vs population) ( 33307546) Crohn's disease ( 21102463 28067908) Inflammatory bowel disease ( 28067908 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602 31604244 21833088) Neutrophil percentage of white cells ( 32888494 27863252) Pediatric autoimmune diseases ( 26301688) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Psoriasis ( 20953190 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Rheumatoid arthritis ( 23143596 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sarcoidosis ( 26051272) Systemic lupus erythematosus ( 27399966 33272962 26502338 28714469) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Type 1 diabetes ( 21829393 19966805 32005708 25751624) Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 30584014)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Allergic rhinitis ( 30013184) Ankylosing spondylitis ( 23749187) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 28067908) Educational attainment ( 25201988) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908 23128233) Inflammatory bowel disease (early onset) ( 19915574) Intelligence (MTAG) ( 29326435) Lamb consumption ( 32066663) Obesity (extreme) ( 30677029) Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		44 interacting genes: CBL COPS5 CRKL CYSRT1 DNM2 EIF2AK2 FHL3 FYN GHR GOLGA6L9 HNRNPK IFNAR1 IFNAR2 IL13RA1 IL6ST IRS1 IRS2 JAK1 JAKMIP1 KHDRBS2 KHDRBS3 KRT31 KRT40 KRTAP6-3 LYN PDGFRB PIK3R1 PLAUR PRDM5 PRMT5 PTAFR PTPN1 PTPN6 PTPRC RACK1 SOCS1 STAM2 STAT1 STAT2 TK1 TP53BP2 TRAF4 VAV1 XRCC5	1 interacting genes: SULT2B1
Entrez ID		7297	6817
HPRD ID		01490	01372
Ensembl ID		ENSG00000105397	ENSG00000196502
Uniprot IDs		A0A8V8TN50 A0A8V8TPX5 H0YCT7 H0YE24 P29597	P50225
PDB IDs		3LXN 3LXP 3NYX 3NZ0 3ZON 4GFO 4GIH 4GII 4GJ2 4GJ3 4GVJ 4OLI 4PO6 4PY1 4WOV 5C01 5C03 5F1Z 5F20 5TKD 5WAL 6AAM 6DBK 6DBM 6NSL 6NZE 6NZF 6NZH 6NZP 6NZQ 6NZR 6OVA 6VNS 6VNV 6VNX 6VNY 6X8F 6X8G 7AX4 7K7O 7K7Q 7UYR 7UYS 7UYT 7UYU 8EXN 8EYC 8S98 8S99 8S9A 8TB5 8TB6	1LS6 1Z28 2D06 3QVU 3QVV 3U3J 3U3K 3U3M 3U3O 3U3R 4GRA
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Signal Transduction Phosphotyrosine Residue Binding Growth Hormone Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Multicellular Organismal Process SH3 Domain Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Via JAK-STAT Receptor Complex SH2 Domain Binding Response To External Biotic Stimulus Cytokine Binding Phosphatidylinositol 3-kinase Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Enzyme Binding Response To Peptide Hormone Regulation Of Signaling Regulation Of Cell Communication Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Cytosol Regulation Of MAPK Cascade Cellular Response To Insulin Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of Cell Adhesion Type I Interferon-mediated Signaling Pathway Response To Other Organism Response To Insulin Insulin Receptor Binding Positive Regulation Of Cell-cell Adhesion Response To Platelet-derived Growth Factor Regulation Of Defense Response Protein Kinase Binding Phosphatidylinositol 3-kinase Activator Activity Cellular Response To Peptide Hormone Stimulus Lymphocyte Proliferation Ephrin Receptor Binding Mononuclear Cell Proliferation Regulation Of Macromolecule Biosynthetic Process	Alcohol Sulfotransferase Activity 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Cholesterol Sulfotransferase Activity Steroid Sulfotransferase Activity Steroid Hormone Binding Type II Interferon-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Growth Hormone Receptor Binding Interleukin-10-mediated Signaling Pathway Interleukin-12 Receptor Complex Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Natural Killer Cell Proliferation Regulation Of Natural Killer Cell Proliferation Extrinsic Component Of Plasma Membrane Positive Regulation Of NK T Cell Proliferation Interleukin-12-mediated Signaling Pathway Interleukin-23 Receptor Complex Type III Interferon-mediated Signaling Pathway Positive Regulation Of NK T Cell Activation Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Sulfation Positive Regulation Of T-helper 17 Type Immune Response Small Molecule Binding Growth Hormone Receptor Signaling Pathway Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Interleukin-17 Production Positive Regulation Of Epidermal Cell Differentiation Positive Regulation Of Epidermis Development Sulfotransferase Activity Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Natural Killer Cell Activation Regulation Of T-helper 17 Type Immune Response Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Receptor Signaling Pathway Via STAT Cholesterol Binding Phosphate-containing Compound Metabolic Process Type I Interferon-mediated Signaling Pathway Regulation Of Epidermal Cell Differentiation Regulation Of Epidermis Development Positive Regulation Of Epithelial Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Type II Interferon Production Interferon-mediated Signaling Pathway Cellular Response To Virus Positive Regulation Of Alpha-beta T Cell Activation Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Via STAT Transferase Activity
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