TUFM and DOC2A

		TUFM	DOC2A
Description		Tu translation elongation factor, mitochondrial	double C2 domain alpha
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Membrane Mitochondrial Nucleoid Extracellular Exosome	Lysosome Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuron Projection Synapse Extrinsic Component Of Synaptic Vesicle Membrane Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding	Protein Binding Calcium-dependent Phospholipid Binding Metal Ion Binding
	Biological Process	Translation Translational Elongation Mitochondrial Translational Elongation	Exocytosis Chemical Synaptic Transmission Nervous System Development Synaptic Vesicle Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Spontaneous Neurotransmitter Secretion Calcium-dependent Activation Of Synaptic Vesicle Fusion
Pathways		Mitochondrial translation elongation SARS-CoV-2 modulates autophagy
Drugs		Zinc Guanosine-5'-Diphosphate Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Combined oxidative phosphorylation deficiency (COXPD)
GWAS		Alcohol consumption (drinks per week) ( 30643258) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat percentage ( 26833246) Body mass index ( 20935630) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 28067908) Educational attainment ( 25201988) Estimated glomerular filtration rate ( 31152163) Extremely high intelligence ( 29520040) Hip circumference adjusted for BMI ( 25673412) Inflammatory bowel disease ( 28067908) Intelligence ( 28530673) Lamb consumption ( 32066663) Walking pace ( 33128006)	Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Height ( 28552196) Schizophrenia ( 25056061 28991256 29483656)
Interacting Genes		20 interacting genes: ARL6IP1 ASPH ATP6V1A CMTM5 DGAT2L6 EXOSC6 FAM9B FUNDC1 HMBOX1 LINC01554 MTIF3 MYH9 OGT PCAT1 PTEN RHBDD2 SYP TNFRSF10D XIAP ZDHHC15	6 interacting genes: DYNLT1 FOXP1 RAP1GDS1 STXBP1 UBASH3B UNC13B
Entrez ID		7284	8448
HPRD ID		03861	05195
Ensembl ID		ENSG00000178952	ENSG00000149927
Uniprot IDs		A0A384ME17 P49411	Q14183
PDB IDs		7A5G 7O9K	4MJJ
Enriched GO Terms of Interacting Partners?			Dense Core Granule Exocytosis Neuronal Dense Core Vesicle Exocytosis Regulation Of Synaptic Vesicle Priming Syntaxin-1 Binding Synaptic Vesicle Priming Negative Regulation Of Cell Differentiation Secretory Granule Localization Nuclear Androgen Receptor Binding Calcium-ion Regulated Exocytosis Negative Regulation Of Developmental Process Vesicle Docking Involved In Exocytosis Regulation Of Cell Communication Regulation Of Signaling CAAX-box Protein Maturation Platelet Aggregation Positive Regulation Of Vesicle Docking Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Positive Regulation Of Synaptic Vesicle Priming Establishment Of Organelle Localization Negative Regulation Of Cell Development Vesicle Docking Homotypic Cell-cell Adhesion Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Organelle Localization By Membrane Tethering Intracellular Transport Of Viral Protein In Host Cell Dense Core Granule Priming Positive Regulation Of Interleukin-21 Production Membrane Docking Regulation Of Signal Transduction Axon Target Recognition Regulation Of Acrosomal Vesicle Exocytosis Regulation Of Cell Development Negative Regulation Of Neuron Maturation Basal Dendrite Morphogenesis Basal Dendrite Arborization Regulated Exocytosis Establishment Of Vesicle Localization Myosin Filament Assembly Extrinsic Component Of Presynaptic Membrane Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Glutamate Secretion, Neurotransmission Negative Regulation Of Synaptic Transmission, GABAergic Regulation Of Cell Differentiation [heparan Sulfate]-glucosamine 3-sulfotransferase Activity Regulation Of Transport Platelet Degranulation Vesicle Localization Regulation Of Glutamate Secretion, Neurotransmission
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