TUFM and FUNDC1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		TUFM	FUNDC1
Description		Tu translation elongation factor, mitochondrial	FUN14 domain containing 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Membrane Mitochondrial Nucleoid Extracellular Exosome	Mitochondrion Mitochondrial Outer Membrane Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding RNA Binding Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding	Protein Binding
	Biological Process	Translation Translational Elongation Mitochondrial Translational Elongation	Autophagy Of Mitochondrion Mitophagy Response To Hypoxia Autophagy Mitochondrial Fusion
Pathways		Mitochondrial translation elongation SARS-CoV-2 modulates autophagy	Receptor Mediated Mitophagy
Drugs		Zinc Guanosine-5'-Diphosphate Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Combined oxidative phosphorylation deficiency (COXPD)
GWAS		Alcohol consumption (drinks per week) ( 30643258) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat percentage ( 26833246) Body mass index ( 20935630) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 28067908) Educational attainment ( 25201988) Estimated glomerular filtration rate ( 31152163) Extremely high intelligence ( 29520040) Hip circumference adjusted for BMI ( 25673412) Inflammatory bowel disease ( 28067908) Intelligence ( 28530673) Lamb consumption ( 32066663) Walking pace ( 33128006)	Facial morphology (factor 22) ( 28441456) Personality dimensions ( 18957941)
Interacting Genes		20 interacting genes: ARL6IP1 ASPH ATP6V1A CMTM5 DGAT2L6 EXOSC6 FAM9B FUNDC1 HMBOX1 LINC01554 MTIF3 MYH9 OGT PCAT1 PTEN RHBDD2 SYP TNFRSF10D XIAP ZDHHC15	15 interacting genes: CTBP1 CTBP2 EHHADH GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B MARCHF5 MTERF3 SENP2 SH3GLB1 SLC25A46 SNX1 TUFM YES1
Entrez ID		7284	139341
HPRD ID		03861	06658
Ensembl ID		ENSG00000178952	ENSG00000069509
Uniprot IDs		A0A384ME17 P49411	Q8IVP5
PDB IDs		7A5G 7O9K	2N9X 5GMV
Enriched GO Terms of Interacting Partners?			Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagosome Membrane Autophagy Of Mitochondrion Autophagosome Maturation Autophagy Mitophagy Cellular Response To Starvation Mitochondrial Outer Membrane Autophagosome Response To Starvation Autophagosome Assembly Autophagosome Organization Cellular Response To Nutrient Levels Phospholipid Binding Protein-containing Complex Disassembly Macroautophagy Vacuole Organization Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Response To Nutrient Levels White Fat Cell Differentiation GABA Receptor Binding Ubiquitin Protein Ligase Binding Viral Genome Replication Fat Cell Differentiation Mitochondrion Organelle Assembly NAD Binding Cytoplasmic Vesicle Beta-tubulin Binding Transcription Coregulator Binding Catabolic Process Membrane Fission Organelle Membrane Protein-containing Complex Organization Transcription Corepressor Binding Protein Localization To Vacuolar Membrane Microtubule Binding Cellular Response To Amino Acid Starvation Transcription Repressor Complex Response To Amino Acid Starvation Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Mitochondrial Membrane Fission Cellular Component Assembly Positive Regulation Of Membrane Tubulation Microtubule Delta(3)-delta(2)-enoyl-CoA Isomerase Activity Retromer, Tubulation Complex Leptin Receptor Binding
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