RNF208 and USP54

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RNF208	USP54
Description		ring finger protein 208	ubiquitin specific peptidase 54
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity K63-linked Deubiquitinase Activity
	Biological Process	Protein Ubiquitination Protein Autoubiquitination	Proteolysis Protein Deubiquitination
Pathways
Drugs
Diseases
GWAS			Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		18 interacting genes: BUD31 CREB5 DAZAP2 GRB2 HOXA1 KRTAP15-1 KRTAP26-1 LITAF OXER1 PIN1 RNF38 RPIA SH3RF1 STAC TRIM32 UBQLN1 UBQLN2 USP54	89 interacting genes: ANKRD11 ANKS1A ARMC7 ATN1 ATXN1 ATXN1L ATXN7L2 BFSP2 BHLHE40 CARD10 CCDC13 CCDC24 CCNK CDC23 CHCHD2 CHERP CHMP1B CHMP2A CHMP2B CHMP4C CSTF2 CYSRT1 DMRT3 DOK6 DTX2 DYRK1A EIF4E2 EPM2AIP1 EXOC8 FAM124B FBXO17 FNDC3B FOXI1 GCM2 HGS HNF1B HNRNPF HOXC8 IGFN1 INSC KCTD9 LMO3 LNX1 MED25 MID2 NUDT22 NXT2 OIP5 OTX1 PCSK5 PHF1 PLA2G6 PLAC8 PLEKHN1 POLR1C PRDM6 PRKAB2 PRR35 QRICH1 RACK1 RAMAC RBPMS2 RHOBTB3 RNF208 SEC24A SHARPIN SHC3 SMARCD1 SMYD1 SNRPB SS18L1 STK16 TBX6 TCEA2 TEKT5 TENT5B TFAP2D TLE5 TNS2 TOLLIP TSEN15 TSSK3 TTC19 UBC USP2 VENTX ZCCHC14 ZNF148 ZNF76
Entrez ID		727800	159195
HPRD ID			15641
Ensembl ID		ENSG00000212864	ENSG00000166348
Uniprot IDs		Q9H0X6	A0A7P0T9K1 B7Z7X1 Q70EL1
PDB IDs			8C61
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Autophagosome Positive Regulation Of Metabolic Process Autophagosome Organization Autophagosome Assembly Positive Regulation Of ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process WW Domain Binding Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Guanyl-nucleotide Exchange Factor Adaptor Activity Semicircular Canal Formation Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cis-trans Isomerase Activity Ribose-5-phosphate Isomerase Activity Vacuole Organization Positive Regulation Of Interleukin-17-mediated Signaling Pathway Actin Ubiquitination Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Regulation Of Proteolysis Regulation Of Macroautophagy Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Store-operated Calcium Channel Activity 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic Acid Binding Positive Regulation Of Protein Metabolic Process Regulation Of Autophagosome Assembly Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Grb2-EGFR Complex Abducens Nerve Formation Optokinetic Behavior Cytoplasmic Side Of Late Endosome Membrane Protein Localization To Phagocytic Vesicle Regulation Of Vacuole Organization Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Peptidyl-prolyl Isomerization Phosphothreonine Residue Binding Protein Polymerization Transcription Coactivator Activity D-ribose Metabolic Process	Membrane Fission ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Multivesicular Body Membrane Multivesicular Body-lysosome Fusion Viral Budding From Plasma Membrane Multivesicular Body Assembly Lysosomal Membrane Organization Multivesicular Body Organization Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Late Endosome To Lysosome Transport Kinetochore Microtubule Mitotic Metaphase Chromosome Alignment Endosome Organization Multivesicular Body Sorting Pathway Viral Budding Via Host ESCRT Complex Regulation Of Mitotic Spindle Assembly Midbody Abscission Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process Protein Binding Metaphase Chromosome Alignment Plasma Membrane Repair ESCRT III Complex Disassembly Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Release From Host Cell ESCRT Complex Disassembly Regulation Of Spindle Assembly Regulation Of Transcription By RNA Polymerase II Cytokinetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Mitotic Spindle Organization Chromosome Localization Regulation Of Macromolecule Biosynthetic Process Multivesicular Body Regulation Of RNA Metabolic Process POZ Domain Binding Regulation Of Centrosome Duplication Nuclear Membrane Organization Regulation Of Primary Metabolic Process Autophagosome Maturation Autophagosome Membrane Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process
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