ARMC12 and TTPA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARMC12	TTPA
Description		armadillo repeat containing 12	alpha tocopherol transfer protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Outer Membrane Membrane	Cytoplasm Late Endosome Cytosol
	Molecular Function	Protein Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Vitamin E Binding Phosphatidylinositol-3,4-bisphosphate Binding Lipid Transfer Activity Phosphatidylinositol Bisphosphate Binding
	Biological Process	Spermatogenesis Cell Differentiation Positive Regulation Of Cell Growth Flagellated Sperm Motility Sperm Mitochondrial Sheath Assembly	Placenta Development Embryonic Placenta Development Lipid Metabolic Process Response To Toxic Substance Vitamin E Metabolic Process Vitamin Transport Negative Regulation Of Establishment Of Blood-brain Barrier Intermembrane Lipid Transfer Positive Regulation Of Amyloid-beta Clearance
Pathways			Vitamin E transport
Drugs
Diseases			Ataxia with isolated vitamin E deficiency (AVED); Friedreich-like ataxia
GWAS		Depression x herpes simplex 1 infection interaction ( 32564518) Eosinophil percentage of granulocytes ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Response to esketamine (responder status) in treatment resistant depression ( 32724131) Response to esketamine in treatment resistant depression ( 32724131)
Interacting Genes		8 interacting genes: EHHADH FA2H GAD2 RBBP4 SENP2 SNX1 SPG21 TTPA	46 interacting genes: AGTRAP APOA5 APOC2 APP ARFIP2 ARMC12 BIRC7 CISD2 CMTM4 CMTM5 COQ3 CYSRT1 DGAT2L6 DHODH FADS6 FAM114A2 FAM25A FAM25C FAM25G FGF14 FKBP7 GOLGA2 HSD17B11 JOSD2 KRTAP10-7 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 LEUTX MAL2 MRM1 NBPF19 NDUFA7 NOTCH2NLA PEX12 REEP2 RPRM SAR1A SCAMP1 SCAMP5 SDR16C5 SLC35E3 SYNGR3 THAP4 TPD52
Entrez ID		221481	7274
HPRD ID		12901	02685
Ensembl ID		ENSG00000157343	ENSG00000137561
Uniprot IDs		Q5T9G4	P49638
PDB IDs			1OIP 1OIZ 1R5L 5MUE 5MUG 6ZPD
Enriched GO Terms of Interacting Partners?		Small Molecule Biosynthetic Process Carboxylic Acid Biosynthetic Process Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Negative Regulation Of Establishment Of Blood-brain Barrier Sebaceous Gland Cell Differentiation 4-hydroxysphinganine Ceramide Fatty Acyl 2-hydroxylase Activity Free Fatty Acid 2-hydroxylase Activity Glucosylceramide Biosynthetic Process Fatty Acid 2-hydroxylase Activity Regulation Of Sebum Secreting Cell Proliferation Regulation Of Acinar Cell Proliferation Monocarboxylic Acid Metabolic Process Fatty Acid Biosynthetic Process CAF-1 Complex Regulation Of Establishment Of Blood-brain Barrier Vitamin E Binding Central Nervous System Myelin Maintenance Organic Acid Metabolic Process Lyase Activity Carboxylic Acid Metabolic Process Lipid Modification Enoyl-CoA Hydratase Activity (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Delta(3)-delta(2)-enoyl-CoA Isomerase Activity 3-hydroxyacyl-CoA Dehydratase Activity Cytosol Gamma-aminobutyric Acid Biosynthetic Process L-glutamate Catabolic Process Gamma-aminobutyric Acid Metabolic Process Succinate Metabolic Process Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane DNA Replication-dependent Chromatin Assembly NURF Complex Retromer, Tubulation Complex Lamellipodium Morphogenesis Leptin Receptor Binding Vitamin E Metabolic Process Positive Regulation Of Amyloid-beta Clearance SUMO-specific Endopeptidase Activity DeSUMOylase Activity Regulation Of DNA Endoreduplication Galactosylceramide Biosynthetic Process Galactosylceramide Metabolic Process Glucosylceramide Metabolic Process Peripheral Nervous System Myelin Maintenance Carboxylic Acid Catabolic Process Carbon-carbon Lyase Activity	Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Very-low-density Lipoprotein Particle Lipoprotein Lipase Activator Activity High-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Intermediate Filament Lipoprotein Metabolic Process Keratin Filament Positive Regulation Of Triglyceride Catabolic Process Trans-Golgi Network Membrane Triglyceride-rich Lipoprotein Particle Remodeling Chylomicron Phospholipid Efflux
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