MTTP

Name	microsomal triglyceride transfer protein
Structure
Novel Interactors	1 novel interactors: TYK2
Interactors	2 interactors: APOB HSP90B1
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Cytosol Basolateral Plasma Membrane Brush Border Membrane Microvillus Membrane Vesicle Receptor Complex
	Molecular Function	Lipid Transporter Activity Protein Binding Phospholipid Transporter Activity Lipid Binding Apolipoprotein Binding Protein-containing Complex Binding Protein Heterodimerization Activity Phospholipid Transfer Activity Phosphatidylcholine Transfer Activity Cholesterol Transfer Activity Triglyceride Transfer Activity Ceramide 1-phosphate Transfer Activity Phosphatidylethanolamine Transfer Activity
	Biological Process	Lipid Metabolic Process Triglyceride Metabolic Process Lipid Transport Circadian Rhythm Protein Secretion Phospholipid Transport Sterol Transport Triglyceride Transport Low-density Lipoprotein Particle Remodeling Plasma Lipoprotein Particle Assembly Chylomicron Assembly Very-low-density Lipoprotein Particle Assembly Lipoprotein Metabolic Process Cholesterol Homeostasis Lipoprotein Transport Response To Calcium Ion Establishment Of Localization In Cell Intermembrane Lipid Transfer Ceramide 1-phosphate Transport
Pathways	VLDL assembly Chylomicron assembly LDL remodeling
Drugs	Hesperetin Implitapide SLx-4090 Lomitapide
Diseases	Abetalipoproteinemia; Bassen-Kornzweig Disease
GWAS	Alanine aminotransferase levels ( 34315874 ) Aspartate aminotransferase levels ( 34315874 ) Celiac disease ( 23936387 ) HDL cholesterol ( 30275531 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Percent liver fat ( 34128465 ) Regular attendance at a pub or social club ( 29970889 ) Triglyceride levels ( 32203549 )
Entrez ID	4547
HPRD ID	01144
Ensembl ID	ENSG00000138823
Uniprot IDs	B7Z7X3 E9PBP6 P55157
PDB IDs	8EOJ
GO Terms Enriched among Interactors ?	Endocytic Vesicle Lumen Smooth Endoplasmic Reticulum Low-density Lipoprotein Particle Receptor Binding Mature Chylomicron Response To Virus Triglyceride Mobilization Positive Regulation Of Cholesterol Storage Very-low-density Lipoprotein Particle Assembly Lipoprotein Biosynthetic Process Extracellular Exosome Lipoprotein Catabolic Process Chylomicron Remnant Intermediate-density Lipoprotein Particle Lipase Binding Endoplasmic Reticulum Lumen Sequestering Of Calcium Ion Actin Rod Assembly Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum Chaperone Complex Positive Regulation Of Toll-like Receptor Signaling Pathway Sperm Plasma Membrane Protein Folding In Endoplasmic Reticulum Cellular Response To Manganese Ion Interleukin-23-mediated Signaling Pathway Growth Hormone Receptor Binding Interleukin-10-mediated Signaling Pathway Interleukin-12 Receptor Complex Positive Regulation Of Natural Killer Cell Proliferation Extrinsic Component Of Plasma Membrane Positive Regulation Of NK T Cell Proliferation Interleukin-12-mediated Signaling Pathway Interleukin-23 Receptor Complex Type III Interferon-mediated Signaling Pathway Positive Regulation Of NK T Cell Activation Lipoprotein Transport Low-density Lipoprotein Particle Remodeling Chylomicron Low-density Lipoprotein Particle Low-density Lipoprotein Particle Clearance Retrograde Protein Transport, ER To Cytosol Cellular Response To ATP Response To Manganese Ion Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of Natural Killer Cell Proliferation Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Triglyceride Catabolic Process Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of Macrophage Derived Foam Cell Differentiation Very-low-density Lipoprotein Particle