MTTP and HSP90B1

Number of citations of the paper that reports this interaction (PMID 9694898)
19

Data Source:
HPRD (in vivo)

		MTTP	HSP90B1
Gene Name		microsomal triglyceride transfer protein	heat shock protein 90kDa beta (Grp94), member 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Lumen Receptor Complex	Extracellular Region Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Focal Adhesion Membrane Midbody Extracellular Matrix Melanosome Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Endocytic Vesicle Lumen
	Molecular Function	Lipid Transporter Activity Lipid Binding	RNA Binding Calcium Ion Binding Protein Binding ATP Binding Protein Phosphatase Binding Virion Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding
	Biological Process	Lipid Metabolic Process Lipid Transport Lipoprotein Metabolic Process Small Molecule Metabolic Process	Response To Hypoxia Toll-like Receptor Signaling Pathway Protein Folding Receptor-mediated Endocytosis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Protein Transport ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Actin Rod Assembly Negative Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Cellular Protein Metabolic Process Innate Immune Response Sequestering Of Calcium Ion Cellular Response To ATP
Pathways		Lipoprotein metabolism Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Lipid digestion, mobilization, and transport	Toll-Like Receptors Cascades Trafficking and processing of endosomal TLR Scavenging by Class A Receptors ATF6-alpha activates chaperones ATF6-alpha activates chaperone genes Unfolded Protein Response (UPR) Innate Immune System
Drugs		Hesperetin Lomitapide	Rifabutin 2-Chlorodideoxyadenosine 1-Methoxy-2-(2-Methoxyethoxy)Ethane Adenosine-5\'-Diphosphate N-Ethyl-5\'-Carboxamido Adenosine Radicicol METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE
Diseases
GWAS			Coronary heart disease ( 21626137)
Protein-Protein Interactions		2 interactors: APOB HSP90B1	21 interactors: APOB ASGR1 BIRC2 CCT2 CSNK2A1 CSNK2A2 EGFR ERBB2 FANCC HSPA9 LRP1 MAPK6 MDM2 MTTP NKX3-1 POLR2E TG TLR1 TLR2 TLR4 TXNDC11
Entrez ID		4547	7184
HPRD ID		01144	01860
Ensembl ID		ENSG00000138823	ENSG00000166598
Uniprot IDs		E9PBP6 P55157	B4DHT9 P14625
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin Rod Assembly Receptor-mediated Endocytosis Sequestering Of Calcium Ion Response To Selenium Ion Very-low-density Lipoprotein Particle Assembly Protein Catabolic Process Triglyceride Mobilization Cellular Response To ATP Endocytosis Sequestering Of Metal Ion Low-density Lipoprotein Particle Remodeling Chemical Homeostasis Lipoprotein Catabolic Process Protein-lipid Complex Assembly Positive Regulation Of Cholesterol Storage Cellular Response To Prostaglandin Stimulus Lipoprotein Transport Regulation Of Cholesterol Biosynthetic Process Triglyceride Catabolic Process Low-density Lipoprotein Particle Clearance Acylglycerol Catabolic Process Response To Abiotic Stimulus Response To ATP Plasma Lipoprotein Particle Remodeling Cholesterol Efflux Regulation Of Cholesterol Metabolic Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Regulation Of Phosphoprotein Phosphatase Activity Plasma Lipoprotein Particle Clearance ER-associated Ubiquitin-dependent Protein Catabolic Process Homeostatic Process Protein Transport Regulation Of Macrophage Derived Foam Cell Differentiation Cellular Response To Fatty Acid Vesicle-mediated Transport Establishment Of Protein Localization Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Artery Morphogenesis Sperm Motility Regulation Of Lipid Storage Regulation Of Plasma Lipoprotein Particle Levels Artery Development Sterol Transport Cholesterol Transport Catabolic Process Response To Fatty Acid Regulation Of Steroid Biosynthetic Process Cellular Response To Organic Substance	Cellular Response To Stimulus Response To External Stimulus Immune Response-regulating Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Detection Of Molecule Of Bacterial Origin Response To Stimulus Innate Immune Response Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Lipoprotein Transport Cellular Response To Triacyl Bacterial Lipopeptide Detection Of Triacyl Bacterial Lipopeptide Negative Regulation Of Mitotic Cell Cycle Cellular Response To Lipid Detection Of Biotic Stimulus Macrophage Activation Response To Abiotic Stimulus Toll-like Receptor Signaling Pathway Positive Regulation Of Nucleocytoplasmic Transport Immune System Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Immune Response Cell Communication Response To Stress Positive Regulation Of Nitric Oxide Biosynthetic Process Activation Of Innate Immune Response Cellular Metabolic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Immune Response Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Transport Defense Response Cellular Protein Metabolic Process Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Transport Detection Of Bacterial Lipoprotein Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Innate Immune Response Regulation Of Establishment Of Protein Localization Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Cell Proliferation Regulation Of Mitotic Cell Cycle Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Tagcloud ?		apob atherosclerosis atherosclerotic causality esters flox foam inference inherited ldlr master mature mll5 mx1 networks pcl pparg regressed regression regulators remnants responding slows sometimes srsf10 tf thp unstable xrn2	adaptive attenuates attractive carcinogen ceramides chaperone compensatory controversial cre dena diethyl expansion gp96 grp94 hccs hepatocyte hepatocytes hyperplasia maintains nitrosoamine oncogenesis paralog perturbs pharmacologically predisposes probed recombinase steatotic vital
Tagcloud (Difference) ?		apob atherosclerosis atherosclerotic causality esters flox foam inference inherited ldlr master mature mll5 mx1 networks pcl pparg regressed regression regulators remnants responding slows sometimes srsf10 tf thp unstable xrn2	adaptive attenuates attractive carcinogen ceramides chaperone compensatory controversial cre dena diethyl expansion gp96 grp94 hccs hepatocyte hepatocytes hyperplasia maintains nitrosoamine oncogenesis paralog perturbs pharmacologically predisposes probed recombinase steatotic vital
Tagcloud (Intersection) ?