CFI

Description		complement factor I
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Immune System Process Proteolysis Complement Activation Complement Activation, Classical Pathway Innate Immune Response
Pathways		Regulation of Complement cascade
Drugs		Zinc Copper Zinc acetate
Diseases		Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 21665990 23455636) Age-related macular degeneration (geographic atrophy) ( 22705344) Blood protein levels ( 30072576) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Serum alkaline phosphatase levels ( 33339817)
Interacting Genes		3 interacting genes: C3 CFH GLP1R
Entrez ID		3426
HPRD ID		01955
Ensembl ID		ENSG00000205403
Uniprot IDs		A8K3L0 B4DRF2 E7ETH0 G3XAM2 P05156 Q8WW88
PDB IDs		2XRC 5O32
Enriched GO Terms of Interacting Partners?		Complement Activation, Alternative Pathway Regulation Of Complement Activation Symbiont Cell Surface Regulation Of Humoral Immune Response Complement Activation C5L2 Anaphylatoxin Chemotactic Receptor Binding Blood Microparticle Glucagon-like Peptide 1 Receptor Activity Positive Regulation Of Activation Of Membrane Attack Complex Complement-dependent Cytotoxicity Oviduct Epithelium Development Classical-complement-pathway C3/C5 Convertase Complex Positive Regulation Of Type IIa Hypersensitivity Humoral Immune Response Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Glucagon Receptor Activity Response To Psychosocial Stress Regulation Of Complement Activation, Alternative Pathway Positive Regulation Of Complement Activation Complement Activation, Lectin Pathway Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Complement Activation, GZMK Pathway Activation Of Membrane Attack Complex Regulation Of Apoptotic Cell Clearance Immune Effector Process Neuron Remodeling Positive Regulation Of Inflammatory Response To Antigenic Stimulus Synapse Pruning Activation Of Immune Response Positive Regulation Of Apoptotic Cell Clearance Positive Regulation Of Phagocytosis, Engulfment Complement Receptor Mediated Signaling Pathway Post-translational Protein Targeting To Membrane, Translocation Cellular Response To Glucagon Stimulus Activation Of Adenylate Cyclase Activity Serine-type Endopeptidase Complex Regulation Of Complement-dependent Cytotoxicity Complement Component C3b Binding Regulation Of Acute Inflammatory Response To Antigenic Stimulus Opsonization Positive Regulation Of Adenylate Cyclase Activity Heparan Sulfate Proteoglycan Binding Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Lyase Activity Response To Glucagon Positive Regulation Of Humoral Immune Response Positive Regulation Of Lipid Storage Positive Regulation Of Cyclase Activity
Tagcloud ?