CFI and C3

Number of citations of the paper that reports this interaction (PMID 1401896)
29

Data Source:
HPRD (in vitro)

		CFI	C3
Gene Name		complement factor I	complement component 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Scavenger Receptor Activity Metal Ion Binding	Endopeptidase Inhibitor Activity Receptor Binding Protein Binding C5L2 Anaphylatoxin Chemotactic Receptor Binding
	Biological Process	Proteolysis Receptor-mediated Endocytosis Complement Activation, Classical Pathway Regulation Of Complement Activation Innate Immune Response	Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Activation Of Membrane Attack Complex Fatty Acid Metabolic Process Inflammatory Response Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Signal Transduction G-protein Coupled Receptor Signaling Pathway Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Glucose Transport Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Lipid Storage Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Innate Immune Response Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Angiogenesis Regulation Of Immune Response Positive Regulation Of Apoptotic Cell Clearance
Pathways		Regulation of Complement cascade Complement cascade Innate Immune System	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Alternative complement activation Class A/1 (Rhodopsin-like receptors) Activation of C3 and C5 Metabolic disorders of biological oxidation enzymes GPCR ligand binding Initial triggering of complement GPCR downstream signaling Peptide ligand-binding receptors Regulation of Complement cascade Complement cascade G alpha (i) signalling events Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System Innate Immune System
Drugs
Diseases
GWAS		Age-related macular degeneration ( 20385819 20385826 23455636 21665990) Age-related macular degeneration (GA) ( 22705344)	Age-related macular degeneration ( 20385819 20385826 23455636 20861866 21665990) Age-related macular degeneration (CNV) ( 22705344) Age-related macular degeneration (GA) ( 22705344) Complement C3 and C4 levels ( 23028341)
Protein-Protein Interactions		3 interactors: C3 CFH GLP1R	27 interactors: ABL1 C2 C3AR1 C5 C5AR2 CD46 CFB CFH CFHR3 CFHR4 CFHR5 CFI CFP CPN1 CR1 CR2 CTSG GC ITGAM ITGAX LAMA1 LRP1 MASP1 OLFM4 PAPPA TGM2 VSIG4
Entrez ID		3426	718
HPRD ID		01955	00400
Ensembl ID		ENSG00000205403	ENSG00000125730
Uniprot IDs		A8K3L0 E7ETH0 G3XAM2 P05156	P01024
PDB IDs		2XRC	1C3D 1GHQ 1W2S 2A73 2A74 2GOX 2HR0 2I07 2ICE 2ICF 2NOJ 2QKI 2WII 2WIN 2WY7 2WY8 2XQW 2XWB 2XWJ 3D5R 3D5S 3G6J 3L3O 3L5N 3NMS 3OED 3OHX 3OXU 3RJ3 3T4A 4HW5 4HWJ 4I6O 4M76
Enriched GO Terms of Interacting Partners?		Complement Activation, Alternative Pathway Regulation Of Complement Activation Regulation Of Humoral Immune Response Regulation Of Acute Inflammatory Response Complement Activation Protein Activation Cascade Positive Regulation Of Type IIa Hypersensitivity Humoral Immune Response Regulation Of Inflammatory Response Positive Regulation Of Activation Of Membrane Attack Complex Positive Regulation Of Hypersensitivity Regulation Of Protein Processing Positive Regulation Of Apoptotic Cell Clearance Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Apoptotic Cell Clearance Positive Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Positive Regulation Of Immune Response Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Protein Processing Regulation Of Triglyceride Biosynthetic Process CAMP-mediated Signaling Response To Stress Positive Regulation Of Acute Inflammatory Response Innate Immune Response Activation Of Adenylate Cyclase Activity Cyclic-nucleotide-mediated Signaling Regulation Of Immune Response Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Lipid Storage Positive Regulation Of Immune System Process Regulation Of Triglyceride Metabolic Process Positive Regulation Of Immunoglobulin Mediated Immune Response Positive Regulation Of Adenylate Cyclase Activity Cellular Response To Glucagon Stimulus Positive Regulation Of Lyase Activity Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Phagocytosis Positive Regulation Of Glucose Transport Response To Glucagon G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Regulation Of Lipid Storage Positive Regulation Of CAMP Biosynthetic Process Regulation Of Phagocytosis Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Immune Response Regulation Of Immune System Process Defense Response	Complement Activation Regulation Of Complement Activation Protein Activation Cascade Positive Regulation Of Immune Response Regulation Of Immune Response Regulation Of Humoral Immune Response Humoral Immune Response Regulation Of Immune System Process Defense Response Regulation Of Acute Inflammatory Response Positive Regulation Of Immune System Process Complement Activation, Alternative Pathway Regulation Of Inflammatory Response Innate Immune Response Immune Response Immune System Process Response To Stress Regulation Of Protein Processing Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Receptor Mediated Signaling Pathway Leukocyte Mediated Immunity Response To Stimulus Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Protein Metabolic Process Negative Regulation Of Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Adaptive Immune Response Negative Regulation Of Complement Activation Regulation Of Protein Metabolic Process Response To External Stimulus Regulation Of Cytokine Production Negative Regulation Of Immune Response Negative Regulation Of Leukocyte Chemotaxis Chemotaxis Regulation Of Cell Adhesion Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Macrophage Chemotaxis Immune Response-regulating Signaling Pathway Proteolysis Leukocyte Migration Involved In Inflammatory Response Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Leukocyte Migration Cellular Calcium Ion Homeostasis Lymphocyte Proliferation Locomotion
Tagcloud ?		agfi amos autonomic c30 cipn cipn20 concurrent confirmatory consistency convenience cronbach eortc fill gfi items korean loadings neuropathy neurotoxic nfi qlq reliability rmsr satisfactory spss subscale subscales validity version	accordance antioxidants asp assignment boc buckminsterfullerene c60 carboxyfullerene carboxyfullerenes collapse dopaminergic dugan dyes entirely fluoromethylketone fluorophores hoc hydroxydopamine hydroxylase neurotoxin neurotrophic ohda oxidized phenylpyridinium radicals ros saved temporally toxins
Tagcloud (Difference) ?		agfi amos autonomic c30 cipn cipn20 concurrent confirmatory consistency convenience cronbach eortc fill gfi items korean loadings neuropathy neurotoxic nfi qlq reliability rmsr satisfactory spss subscale subscales validity version	accordance antioxidants asp assignment boc buckminsterfullerene c60 carboxyfullerene carboxyfullerenes collapse dopaminergic dugan dyes entirely fluoromethylketone fluorophores hoc hydroxydopamine hydroxylase neurotoxin neurotrophic ohda oxidized phenylpyridinium radicals ros saved temporally toxins
Tagcloud (Intersection) ?