IFI16

Description		interferon gamma inducible protein 16
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck
	Molecular Function	DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Transcription Factor Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cytokine Production Activation Of Innate Immune Response Immune System Process Autophagy Apoptotic Process Inflammatory Response Regulation Of Autophagy Myeloid Cell Differentiation Monocyte Differentiation Positive Regulation Of Interleukin-1 Beta Production Cellular Response To Interferon-beta Cellular Response To Glucose Starvation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Binding Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Innate Immune Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Defense Response To Virus Cellular Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of AIM2 Inflammasome Complex Assembly
Pathways		STING mediated induction of host immune responses IRF3-mediated induction of type I IFN
Drugs
Diseases
GWAS		C-reactive protein ( 22939635) Celiac disease or Rheumatoid arthritis ( 21383967) Lymphocyte percentage of white cells ( 32888494) Neutrophil count in HIV-infection ( 25884002) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Periodontal disease-related phenotype (Socransky) ( 26962152)
Interacting Genes		13 interacting genes: APP AR AURKA BRCA1 CEBPA CSNK2A1 ID1 ID2 ID3 STING1 TP53 TP53BP1 TPR
Entrez ID		3428
HPRD ID		00969
Ensembl ID		ENSG00000163565
Uniprot IDs		Q16666
PDB IDs		2OQ0 3B6Y 3RLN 3RLO 3RNU 4QGU 8X70
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Cell Cycle Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle Phase Transition Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Developmental Process Intracellular Signal Transduction DNA Damage Checkpoint Signaling Molecular Function Activator Activity Rhythmic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Process Positive Regulation Of Biosynthetic Process Regulation Of Signal Transduction By P53 Class Mediator Circadian Rhythm Regulation Of Mitotic Cell Cycle Phase Transition Protein Localization To Organelle Transcription Regulator Inhibitor Activity Regulation Of Cell Differentiation Regulation Of Osteoblast Differentiation
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