TNNI1 and EIF3I

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
BioGRID (two hybrid)

		TNNI1	EIF3I
Gene Name		troponin I type 1 (skeletal, slow)	eukaryotic translation initiation factor 3, subunit I
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Troponin Complex	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Extracellular Vesicular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Actin Binding Metal Ion Binding	Translation Initiation Factor Activity Protein Binding
	Biological Process	Regulation Of Striated Muscle Contraction Muscle Filament Sliding Ventricular Cardiac Muscle Tissue Morphogenesis	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process
Pathways		Striated Muscle Contraction	Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: ACTA1 CCDC85B EIF3I MDFI PKD2L1 PNMA1 TNNC1 TNNT1 TNNT2 TRIM55 TRIM63	34 interactors: EIF3A EIF3B EIF4G1 ESR1 ESR2 ESRRA ESRRG EXOSC6 HARS HNF4G LAMB1 LAMC1 LIG4 NR1H3 NR1I2 NR1I3 NR3C2 PAXIP1 PDC PDCL PPARD PSMC4 RARB RARG RORA RORB RORC SUMO4 TGFB1 TGFBR2 THRB TNNI1 VDR VIM
Entrez ID		7135	8668
HPRD ID		01842	04884
Ensembl ID		ENSG00000159173	ENSG00000084623
Uniprot IDs		P19237	Q13347 Q5U0F4
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle Contraction Muscle System Process Negative Regulation Of ATPase Activity Skeletal Muscle Adaptation Regulation Of Muscle Contraction Skeletal Muscle Contraction Actin Filament-based Process Regulation Of ATPase Activity Musculoskeletal Movement Ventricular Cardiac Muscle Tissue Morphogenesis Muscle Organ Development Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Striated Muscle Tissue Development Muscle Tissue Morphogenesis Response To Metal Ion Muscle Tissue Development Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Regulation Of Muscle Filament Sliding Speed Myofibril Assembly Striated Muscle Contraction Skeletal Muscle Fiber Adaptation Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Cardiac Ventricle Development Response To Inorganic Substance Actomyosin Structure Organization Muscle Structure Development Regulation Of Muscle Filament Sliding Diaphragm Contraction Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Cardiac Chamber Development Sensory Perception Of Sour Taste Involuntary Skeletal Muscle Contraction Striated Muscle Cell Development Skeletal Muscle Atrophy Muscle Cell Development Slow-twitch Skeletal Muscle Fiber Contraction Skeletal Muscle Thin Filament Assembly Striated Muscle Atrophy Cardiac Muscle Tissue Development Movement Of Cell Or Subcellular Component Cellular Response To Acidic PH Muscle Atrophy Atrial Cardiac Muscle Tissue Morphogenesis	Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Intracellular Receptor Signaling Pathway Response To Steroid Hormone Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Cellular Response To Hormone Stimulus Response To Hormone Response To Lipid Response To Organic Cyclic Compound Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Response To Organic Substance Macromolecule Biosynthetic Process Tissue Development Positive Regulation Of Cellular Metabolic Process Transcription, DNA-templated Signal Transduction Biosynthetic Process RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Signaling Response To Stimulus Connective Tissue Development Cell Communication Organ Development Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stimulus Nitrogen Compound Metabolic Process System Development Regulation Of Metabolic Process Negative Regulation Of Gene Expression Multicellular Organismal Development Negative Regulation Of Transcription, DNA-templated
Tagcloud ?			advantages akt array chaperone clinicopathological clu clusterin complexing confers correlations ectopic eukaryotic facilitates forced hcc hepatocellular inhibiting metalloproteinase metastasis mmp13 ogx option proliferative promoted shorter silencing suppressing turn utilized
Tagcloud (Difference) ?			advantages akt array chaperone clinicopathological clu clusterin complexing confers correlations ectopic eukaryotic facilitates forced hcc hepatocellular inhibiting metalloproteinase metastasis mmp13 ogx option proliferative promoted shorter silencing suppressing turn utilized
Tagcloud (Intersection) ?