TLL2 and RBP4

Data Source: HiPPIP (Novel)

		TLL2	RBP4
Name		tolloid like 2	retinol binding protein 4
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Protein-containing Complex Extracellular Exosome
	Molecular Function	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Retinoid Binding Protein Binding Retinal Binding Retinol Binding Retinol Transmembrane Transporter Activity Protein-containing Complex Binding Molecular Carrier Activity
	Biological Process	Proteolysis Dorsal/ventral Pattern Formation Protein Processing Cell Differentiation Collagen Fibril Organization Negative Regulation Of Skeletal Muscle Tissue Growth	Retinoid Metabolic Process Eye Development Positive Regulation Of Immunoglobulin Production Gluconeogenesis Spermatogenesis Heart Development Visual Perception Phototransduction, Visible Light Male Gonad Development Response To Xenobiotic Stimulus Response To Muscle Activity Maintenance Of Gastrointestinal Epithelium Lung Development Positive Regulation Of Insulin Secretion Response To Retinoic Acid Response To Insulin Retinol Transport Retinol Metabolic Process Retinal Metabolic Process Glucose Homeostasis Response To Ethanol Embryonic Organ Morphogenesis Embryonic Skeletal System Development Cardiac Muscle Tissue Development Female Genitalia Morphogenesis Detection Of Light Stimulus Involved In Visual Perception Retina Development In Camera-type Eye Negative Regulation Of Cardiac Muscle Cell Proliferation Embryonic Retina Morphogenesis In Camera-type Eye Uterus Development Vagina Development Urinary Bladder Development Heart Trabecula Formation Vitamin A Import Into Cell
Pathways		Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils	The canonical retinoid cycle in rods (twilight vision) Retinoid metabolism disease events Retinoid metabolism and transport Defective visual phototransduction due to STRA6 loss of function
Drugs		Methyl N-{[(1R)-1-({1-[(benzyloxy)carbonyl]-L-prolyl-6-ammonio-L-norleucyl}amino)-2-phenylethyl](hydroxy)phosphoryl}-L-alanyl-L-prolinate	Tretinoin
GWAS		Attention deficit hyperactivity disorder ( 18839057 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Platelet reactivity in response to clopidogrel treatment ( 32472697 ) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770 )	Blood protein levels ( 30072576 ) Optic disc area ( 31798171 ) Retinol levels ( 21878437 )
Novel Interactors		5 novel interactors: DNTT HPSE2 PAPSS2 PPP1R3C RBP4	1 novel interactors: TLL2
Interacting Genes		None recorded	7 interacting genes: ALB GRB2 LAMTOR5 RBBP6 RIPPLY3 RPE65 TTR
Entrez ID		7093	5950
HPRD ID		05993	01580
Ensembl ID		ENSG00000095587	ENSG00000138207
Uniprot IDs		Q9Y6L7	P02753 Q5VY30
PDB IDs		Not available	1BRP 1BRQ 1JYD 1JYJ 1QAB 1RBP 1RLB 2WQ9 2WQA 2WR6 3BSZ 3FMZ 4O9S 4PSQ 5NTY 5NU2 5NU6 5NU7 5NU8 5NU9 5NUA 5NUB 6QBA
GO Terms Enriched among Interactors		Nucleotidyltransferase Activity DNA Nucleotidylexotransferase Activity Carbohydrate Biosynthetic Process Vitamin A Import Into Cell 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process Sulfate Assimilation Sulfate Adenylyltransferase (ATP) Activity Adenylylsulfate Kinase Activity Heparanase Activity Retinol Transmembrane Transporter Activity Female Genitalia Morphogenesis Retinol Transport Hormone Metabolic Process Terpenoid Transport Urinary Bladder Development Embryonic Retina Morphogenesis In Camera-type Eye Glycogen Binding Retinoid Binding Retinal Binding Vagina Development DNA Polymerase Activity Carbohydrate Metabolic Process Protein Phosphatase Type 1 Complex Glycogen Biosynthetic Process Molecular Carrier Activity Genitalia Morphogenesis Heart Trabecula Formation Retinol Binding Lipid Import Into Cell Retinal Metabolic Process Negative Regulation Of Cardiac Muscle Cell Proliferation Female Genitalia Development Vitamin Transmembrane Transport Phototransduction, Visible Light 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Heparan Sulfate Proteoglycan Binding Detection Of Light Stimulus Involved In Visual Perception DNA-directed DNA Polymerase Activity Uterus Development Protein Phosphatase 1 Binding Polysaccharide Biosynthetic Process Detection Of Visible Light Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Cardiac Muscle Tissue Growth DNA Modification Regulation Of Glycogen Biosynthetic Process Response To Muscle Activity Response To ATP Regulation Of Hormone Levels Negative Regulation Of Organ Growth	Protein-containing Complex Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Guanyl-nucleotide Exchange Factor Adaptor Activity Response To Radiation Grb2-EGFR Complex Terpenoid Metabolic Process All-trans-retinyl-palmitate Hydrolase, 11-cis Retinol Forming Activity Retinoid Metabolic Process All-trans-retinyl-ester Hydrolase, 11-cis Retinol Forming Activity Zeaxanthin Biosynthetic Process Retinol Isomerase Activity Diterpenoid Metabolic Process Xanthophyll Metabolic Process Detection Of Light Stimulus Negative Regulation Of Skeletal Muscle Tissue Growth Isoprenoid Metabolic Process Carotenoid Metabolic Process Beta-carotene 15,15'-dioxygenase Activity Detection Of Abiotic Stimulus Negative Regulation Of Glomerular Filtration Ragulator Complex Neurotrophin TRKA Receptor Binding Vitamin A Metabolic Process Regulation Of Skeletal Muscle Tissue Growth