TLL2 and PAPSS2

Data Source: HiPPIP (Novel)

		TLL2	PAPSS2
Name		tolloid like 2	3'-phosphoadenosine 5'-phosphosulfate synthase 2
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleus Cytosol
	Molecular Function	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Nucleotide Binding Catalytic Activity Adenylylsulfate Kinase Activity Sulfate Adenylyltransferase (ATP) Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Nucleotidyltransferase Activity
	Biological Process	Proteolysis Dorsal/ventral Pattern Formation Protein Processing Cell Differentiation Collagen Fibril Organization Negative Regulation Of Skeletal Muscle Tissue Growth	Sulfate Assimilation Hormone Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process
Pathways		Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils	Transport and metabolism of PAPS Metabolism of ingested H2SeO4 and H2SeO3 into H2Se Defective PAPSS2 causes SEMD-PA
Drugs		Methyl N-{[(1R)-1-({1-[(benzyloxy)carbonyl]-L-prolyl-6-ammonio-L-norleucyl}amino)-2-phenylethyl](hydroxy)phosphoryl}-L-alanyl-L-prolinate	None
Diseases		None	SEMD, Pakistani type
GWAS		Attention deficit hyperactivity disorder ( 18839057 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Platelet reactivity in response to clopidogrel treatment ( 32472697 ) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770 )	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Heel bone mineral density ( 30598549 ) Leisure-time exercise behaviour ( 19727025 ) Magnesium levels ( 26685716 ) Serum metabolite levels ( 33031748 )
Novel Interactors		5 novel interactors: DNTT HPSE2 PAPSS2 PPP1R3C RBP4	2 novel interactors: CD83 TLL2
Interacting Genes		None recorded	4 interacting genes: APP CEP19 DAPK1 HSF2BP
Entrez ID		7093	9060
HPRD ID		05993	04303
Ensembl ID		ENSG00000095587	ENSG00000198682
Uniprot IDs		Q9Y6L7	O95340 Q5TB52
PDB IDs		Not available	2AX4 7FH3 7FHA 8I1N 8I1O
GO Terms Enriched among Interactors		Nucleotidyltransferase Activity DNA Nucleotidylexotransferase Activity Carbohydrate Biosynthetic Process Vitamin A Import Into Cell 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process Sulfate Assimilation Sulfate Adenylyltransferase (ATP) Activity Adenylylsulfate Kinase Activity Heparanase Activity Retinol Transmembrane Transporter Activity Female Genitalia Morphogenesis Retinol Transport Hormone Metabolic Process Terpenoid Transport Urinary Bladder Development Embryonic Retina Morphogenesis In Camera-type Eye Glycogen Binding Retinoid Binding Retinal Binding Vagina Development DNA Polymerase Activity Carbohydrate Metabolic Process Protein Phosphatase Type 1 Complex Glycogen Biosynthetic Process Molecular Carrier Activity Genitalia Morphogenesis Heart Trabecula Formation Retinol Binding Lipid Import Into Cell Retinal Metabolic Process Negative Regulation Of Cardiac Muscle Cell Proliferation Female Genitalia Development Vitamin Transmembrane Transport Phototransduction, Visible Light 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Heparan Sulfate Proteoglycan Binding Detection Of Light Stimulus Involved In Visual Perception DNA-directed DNA Polymerase Activity Uterus Development Protein Phosphatase 1 Binding Polysaccharide Biosynthetic Process Detection Of Visible Light Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Cardiac Muscle Tissue Growth DNA Modification Regulation Of Glycogen Biosynthetic Process Response To Muscle Activity Response To ATP Regulation Of Hormone Levels Negative Regulation Of Organ Growth	Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Vesicle Targeting, Trans-Golgi To Periciliary Membrane Compartment Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of NMDA Receptor Activity Negative Regulation Of Skeletal Muscle Tissue Growth Vesicle Targeting, To, From Or Within Golgi Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Interleukin-4 Production Female Meiosis I Peptidase Activator Activity Cellular Response To Manganese Ion Extracellular Matrix Organization Extracellular Structure Organization Heparan Sulfate Binding Signaling Receptor Activator Activity Cellular Response To Hydroperoxide Humoral Immune Response Defense Response To Tumor Cell