THRSP and LSP1

Number of citations: 0 (PubMedID 25640309)
Data Source: BioGRID (two hybrid)

		THRSP	LSP1
Name		thyroid hormone responsive	lymphocyte specific protein 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Plasma Membrane Actin Cytoskeleton Membrane Extracellular Exosome
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity Molecular Function Inhibitor Activity	Actin Binding Protein Binding
	Biological Process	Lipid Metabolic Process Response To Bacterium Regulation Of Triglyceride Biosynthetic Process Regulation Of Lipid Biosynthetic Process	Chemotaxis Defense Response Cellular Defense Response Signal Transduction Cellular Response To Interleukin-7
Pathways		Carnitine shuttle MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	None
GWAS		Menarche (age at onset) ( 25231870 ) Tourette syndrome ( 30818990 )	Bladder cancer ( 24163127 ) Breast cancer ( 20453838 17529967 23535729 29059683 27117709 ) Breast cancer (estrogen-receptor negative) ( 27117709 ) Celiac disease ( 23936387 ) Central corneal thickness ( 32528159 ) Diastolic blood pressure ( 30487518 27618452 27841878 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Hypertension ( 30487518 ) Inflammatory bowel disease ( 28067908 23128233 ) Lymphocyte count ( 32888494 ) Mammographic density (dense area) ( 25342443 ) Mean arterial pressure ( 29403010 30487518 ) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962 ) Medication use (antihypertensives) ( 31015401 ) Medication use (beta blocking agents) ( 31015401 ) Methadone dose in opioid dependence ( 28115739 ) Milk allergy ( 25710614 ) Monocyte count ( 32888494 27863252 ) Monocyte percentage of white cells ( 32888494 27863252 ) Potassium levels ( 29403010 ) Pulse pressure ( 30578418 27841878 ) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962 ) Systolic blood pressure ( 27618452 29403010 30487518 30578418 27841878 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Ulcerative colitis ( 28067908 21297633 )
Novel Interactors		1 novel interactors: SLAMF7	None recorded
Interacting Genes		25 interacting genes: AKT1 AURKA BAG4 BCAR3 BRMS1 ERBB2 FGFR4 FZR1 HMMR IGF1R INCA1 KRAS LSP1 PALB2 PARP1 PIK3CA PTPN1 RB1CC1 SMAD4 STK11 TEPSIN TGFB1 TSG101 WT1 ZMYND12	11 interacting genes: ACTG1 BMPR2 CFTR GREB1 IL24 KLK6 LYPD3 MAPKAPK2 SCGB2A2 SNAI1 THRSP
Entrez ID		7069	4046
HPRD ID		03566	01083
Ensembl ID		ENSG00000151365	ENSG00000130592
Uniprot IDs		Q92748	A8K7L8 P33241
PDB IDs		Not available	3BH8 4NO0 4NO2
GO Terms Enriched among Interactors		Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Cell Population Proliferation Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Carbohydrate Homeostasis Glucose Homeostasis Negative Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Cell Communication Regulation Of Signaling Insulin Receptor Signaling Pathway Gland Development Cellular Response To Growth Factor Stimulus Apoptotic Process Response To Growth Factor Regulation Of Cellular Component Organization Positive Regulation Of Cell Population Proliferation Liver Development Programmed Cell Death Cell Death Anoikis Negative Regulation Of Cell Population Proliferation Protein-containing Complex Binding Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Epithelial Cell Differentiation Regulation Of Cell Growth Positive Regulation Of Fibroblast Migration Regulation Of Growth Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Glucose Stimulus Regulation Of Protein Modification Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Regulation Of Protein Localization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Carbohydrate Stimulus ERBB Signaling Pathway Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Catalytic Activity Cell Population Proliferation	None