JMJD1C

Description		jumonji domain containing 1C
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm
	Molecular Function	Transcription Coregulator Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Chromatin DNA Binding Histone H3K9 Demethylase Activity Metal Ion Binding Nuclear Thyroid Hormone Receptor Binding Dioxygenase Activity
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Blood Coagulation
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Adult body size ( 32376654) Androgen levels ( 22936694) Apolipoprotein A1 levels ( 32203549) Arthritis (juvenile idiopathic) ( 22354554) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Basophil percentage of granulocytes ( 27863252) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) CXCL5 levels ( 25147954) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Educational attainment ( 25201988) Eosinophil percentage of white cells ( 32888494) Fasting plasma glucose ( 31170924) FEV1 ( 30804560) Fibrinogen ( 23969696) Fibrinogen levels ( 26561523 28107422) Gallstone disease ( 30504769) General cognitive ability ( 29844566) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 31928498) High light scatter reticulocyte count ( 27863252) Household income (MTAG) ( 31844048) Immature fraction of reticulocytes ( 27863252 32888494) Inflammatory biomarkers (multivariate analysis) ( 33110245) Insulin-related traits (multivariate analysis) ( 32002517) Intelligence (MTAG) ( 29326435) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757 33972514) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FEV1) ( 30061609) Lung function (FEV1/FVC) ( 30061609) Lung function (FVC) ( 30804560) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Macular telangiectasia type 2 ( 33654266) Mean platelet volume ( 19820697 22139419 24026423 27863252 28031487 31194788 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Platelet aggregation ( 20526338 29185836) Platelet count ( 22139419 22423221 23263863 24026423 26805783 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) Prothrombin time ( 29403010) Schizophrenia ( 28991256) Serum alkaline phosphatase levels ( 29403010 31666285 33339817) Sex hormone-binding globulin levels ( 22829776) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total bilirubin levels ( 29403010) Triglyceride levels ( 28334899 29403010 31928498 32154731 32203549 33339817) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 20686565 24097068 25961943) Type 2 diabetes ( 28406950 32499647) Urate levels ( 31578528) Vascular endothelial growth factor levels ( 26910538 27989323) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Walking pace ( 33128006) White blood cell count ( 27863252)
Interacting Genes		16 interacting genes: AR ESR2 GADD45A KLHL20 MT2A MYOM2 NR3C1 NUDT21 PPARG PSMC1 RNF168 RNF8 RXRA SRPK2 THRB TK1
Entrez ID		221037
HPRD ID		05141
Ensembl ID		ENSG00000171988
Uniprot IDs		B7ZLC8 Q15652
PDB IDs		2YPD 5FZO 9GDK
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Nuclear Receptor-mediated Signaling Pathway Hormone-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Estrogen Response Element Binding Negative Regulation Of DNA-templated Transcription Steroid Hormone Receptor Signaling Pathway Intracellular Signal Transduction Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nuclear Steroid Receptor Activity Retinoic Acid Receptor Signaling Pathway Zinc Ion Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Steroid Binding Nucleic Acid Metabolic Process Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Chromatin Binding Nucleus DNA Binding Domain Binding Positive Regulation Of Lipoprotein Transport MRNA Transcription By RNA Polymerase II Regulation Of Thyroid Hormone Receptor Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Macromolecule Metabolic Process LBD Domain Binding Nucleobase-containing Compound Metabolic Process Positive Regulation Of MiRNA Transcription DNA-binding Transcription Factor Activity MRNA Transcription Enzyme Binding Chromatin Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of MiRNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Transcription By RNA Polymerase II Modification-dependent Protein Catabolic Process Monocyte Differentiation Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding MRNA Metabolic Process
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