THBS1 and KCNQ3

		THBS1	KCNQ3
Description		thrombospondin 1	potassium voltage-gated channel subfamily Q member 3
Image
GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen External Side Of Plasma Membrane Cell Surface Sarcoplasmic Reticulum Secretory Granule Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Lumen Extracellular Exosome	Mitochondrion Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Node Of Ranvier Monoatomic Ion Channel Complex Axon Initial Segment Synapse
	Molecular Function	Phosphatidylserine Binding Fibronectin Binding Protease Binding Endopeptidase Inhibitor Activity Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Heparin Binding Fibroblast Growth Factor Binding Low-density Lipoprotein Particle Binding Protein Homodimerization Activity Laminin Binding Proteoglycan Binding Transforming Growth Factor Beta Binding Extracellular Matrix Binding Fibrinogen Binding Collagen V Binding	Monoatomic Ion Channel Activity Voltage-gated Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding Calmodulin Binding Voltage-gated Monoatomic Cation Channel Activity
	Biological Process	Angiogenesis Response To Hypoxia Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Chronic Inflammatory Response Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Immune System Process Apoptotic Process Inflammatory Response Immune Response Response To Unfolded Protein Cell Adhesion Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Glucose Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Plasminogen Activation Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Fibroblast Migration Regulation Of Cell-substrate Adhesion Cell Migration Negative Regulation Of Angiogenesis Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Magnesium Ion Response To Progesterone Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Transforming Growth Factor Beta1 Production Response To Testosterone Cellular Response To Heat Response To Endoplasmic Reticulum Stress Nitric Oxide-cGMP-mediated Signaling Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Engulfment Of Apoptotic Cell Positive Regulation Of Translation Positive Regulation Of Angiogenesis Behavioral Response To Pain Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Chemotaxis Response To Calcium Ion Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Fibrinolysis Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Transforming Growth Factor Beta Production Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Targeting Protein Import Into Nucleus Monoatomic Ion Transport Potassium Ion Transport Exocytosis Endocytosis Chemical Synaptic Transmission Sensory Perception Of Sound Response To Mechanical Stimulus Gene Expression Response To Auditory Stimulus Protein Transport Neuron Remodeling Neuronal Action Potential Nerve Development Neuron Differentiation Monoatomic Ion Transmembrane Transport Psychomotor Behavior Regulation Of Synaptic Plasticity Neuron Apoptotic Process Establishment Of Localization In Cell Mitochondrial Depolarization Transmembrane Transport Membrane Hyperpolarization Protein-containing Complex Assembly Cellular Response To Calcium Ion Cellular Response To Xenobiotic Stimulus Potassium Ion Transmembrane Transport Apoptosome Assembly Excitatory Chemical Synaptic Transmission Inhibitory Chemical Synaptic Transmission Action Potential Initiation Regulation Of Action Potential Firing Threshold Substantia Propria Of Cornea Development
Pathways		Platelet degranulation Signaling by PDGF Integrin cell surface interactions Syndecan interactions Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Voltage gated Potassium channels Interaction between L1 and Ankyrins
Drugs			Enflurane Amitriptyline Meclofenamic acid Gabapentin Promethazine Miconazole Ezogabine ICA-105665
Diseases
GWAS		Cortical volume ( 32963231) Liver enzyme levels (alanine transaminase) ( 33972514) Logical memory (immediate recall) in normal cognition ( 29274321) Urate levels ( 31578528)	Coronary artery calcification ( 23870195) Height ( 28552196) LDL peak particle diameter (total fat intake interaction) ( 26112879) QT interval ( 29213071) Type 2 diabetes ( 31324766)
Interacting Genes		52 interacting genes: APP BGN CALCR CALR CD36 CD47 CFH COL11A1 COL18A1 COL1A1 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 COL7A1 CORO1A CTSG DCN DHFR DYRK1A ELANE F2 FBN2 FGA FGF2 FN1 HRG HSP90AA1 IGFBP5 ITGB3 JAG1 KNG1 LAMB3 LRP1 LRP2 LRP5 MMP2 MMP9 MTDH PDGFB PLG PLSCR1 SCARB2 SPARC TFPI TGFB1 TGM2 TNFAIP6 TNFRSF11B WEE2-AS1 WWP2	6 interacting genes: CALM1 CALM2 CALM3 KCNQ2 KCNQ4 KCNQ5
Entrez ID		7057	3786
HPRD ID		01765	09077
Ensembl ID		ENSG00000137801	ENSG00000184156
Uniprot IDs		P07996	E7ET42 O43525
PDB IDs		1LSL 1UX6 1Z78 1ZA4 2ERF 2ES3 2OUH 2OUJ 3R6B 5FOE 7YYK	5J03
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Platelet-derived Growth Factor Binding Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Regulation Of Cell Motility Regulation Of Locomotion Platelet Alpha Granule Lumen Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Multicellular Organismal Process Collagen Trimer Regulation Of Signal Transduction Positive Regulation Of Cell Migration Basement Membrane Positive Regulation Of Cell Motility Endodermal Cell Differentiation Regulation Of Cell Adhesion Positive Regulation Of Locomotion Fibrillar Collagen Trimer Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Heparin Binding Regulation Of Hemostasis Cell Surface Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Coagulation Tissue Remodeling Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Wound Healing Animal Organ Morphogenesis Response To Wounding Anatomical Structure Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Blood Coagulation Cell Surface Receptor Signaling Pathway Coagulation Regulation Of Cell-substrate Adhesion Platelet Activation Biological Process Involved In Interaction With Symbiont Positive Regulation Of Multicellular Organismal Process Hemostasis	Voltage-gated Potassium Channel Complex Calyx Of Held Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Titin Binding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Catalytic Complex Negative Regulation Of Transporter Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Transmembrane Transport Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Response To Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Spindle Microtubule Presynaptic Endocytosis Substantia Nigra Development Calcium Channel Regulator Activity Sperm Midpiece Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Voltage-gated Potassium Channel Activity Long-term Synaptic Potentiation Sarcomere Cell Cycle G2/M Phase Transition Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neural Nucleus Development Positive Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Cation Transmembrane Transport Protein Serine/threonine Kinase Activator Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Voltage-gated Calcium Channel Activity Potassium Channel Activity Calcium-dependent Protein Binding Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity
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