PLA2G3

Description		phospholipase A2 group III
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endosome Centriole Cytoskeleton Plasma Membrane Membrane Recycling Endosome
	Molecular Function	Phospholipase Activity Phospholipase A2 Activity Hydrolase Activity Metal Ion Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process	Acrosome Assembly Production Of Molecular Mediator Involved In Inflammatory Response Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylserine Metabolic Process Sperm Axoneme Assembly Negative Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Neuron Projection Development Lipoxygenase Pathway Cell Projection Organization Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Prostaglandin Secretion Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Macrophage Activation Mast Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Differentiation Phosphatidylethanolamine Metabolic Process Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Phosphatidic Acid Metabolic Process Phosphatidylinositol Metabolic Process Cell Development Cell Maturation Arachidonate Secretion Cilium Assembly Positive Regulation Of Mast Cell Differentiation Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Histamine Secretion By Mast Cell Regulation Of Endocytic Recycling
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PE Acyl chain remodelling of PG
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Fish- and plant-related diet ( 32066663) Gut microbiota (beta diversity) ( 27723756) Oily fish consumption ( 32066663) Paclitaxel-induced neuropathy ( 23776197) Pork consumption ( 32066663)
Interacting Genes		3 interacting genes: BTG3 PVR TGFB1I1
Entrez ID		50487
HPRD ID		07144
Ensembl ID		ENSG00000100078
Uniprot IDs		Q9NZ20
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Susceptibility To T Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Roundabout Binding Focal Adhesion Cell Adhesion Mediator Activity Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Response To Tumor Cell Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Immune Response To Tumor Cell Negative Regulation Of Cell Population Proliferation Nuclear Androgen Receptor Binding I-SMAD Binding Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Morphogenesis Of Embryonic Epithelium
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