MMP12

Gene Name		matrix metallopeptidase 12 (macrophage elastase)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Calcium Ion Binding Zinc Ion Binding
	Biological Process	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing
Pathways		Collagen degradation Degradation of the extracellular matrix
Drugs		Acetohydroxamic Acid Marimastat CP-271485 PF-00356231 Batimastat 2-[2-(1,3-Dioxo-1,3-Dihydro-2h-Isoindol-2-Yl)Ethyl]-4-(4\'-Ethoxy-1,1\'-Biphenyl-4-Yl)-4-Oxobutanoic Acid (1S,5S,7R)-N~7~-(BIPHENYL-4-YLMETHYL)-N~3~-HYDROXY-6,8-DIOXA-3-AZABICYCLO[3.2.1]OCTANE-3,7-DICARBOXAMIDE N-(biphenyl-4-ylsulfonyl)-D-leucine N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE N-(dibenzo[b,d]thiophen-3-ylsulfonyl)-L-valine N-oxo-2-[(4-phenylphenyl)sulfonylamino]ethanamide 2-[(4-fluorophenyl)sulfonylamino]-N-oxo-ethanamide N-oxo-2-(phenylsulfonylamino)ethanamide N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID N-[(4-methoxyphenyl)sulfonyl]-D-alanine
Diseases
GWAS		Alzheimer's disease ( 22832961)
Protein-protein Interactions		5 interactors: APP F12 LPA PLAUR TFPI
Entrez ID		4321
HPRD ID		03027
Ensembl ID
Uniprot IDs		P39900
PDB IDs		1JIZ 1JK3 1OS2 1OS9 1RMZ 1ROS 1UTT 1UTZ 1Y93 1YCM 1Z3J 2HU6 2JXY 2K2G 2K9C 2KRJ 2OXU 2OXW 2OXZ 2POJ 2W0D 2WO8 2WO9 2WOA 2Z2D 3BA0 3EHX 3EHY 3F15 3F16 3F17 3F18 3F19 3F1A 3LIK 3LIL 3LIR 3LJG 3LK8 3LKA 3N2U 3N2V 3NX7 3RTS 3RTT 3TS4 3TSK 3UVC 4EFS 4GQL 4GR0 4GR3 4GR8 4GUY 4H30 4H49 4H76 4H84 4I03 4IJO
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Processing Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Regulation Of Proteolysis Response To Wounding Regulation Of Protein Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Fibrinolysis Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Peptidase Activity Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Urokinase Plasminogen Activator Signaling Pathway Regulation Of Wound Healing Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Factor XII Activation Synaptic Growth At Neuromuscular Junction Negative Regulation Of Protein Metabolic Process Protein Activation Cascade Lipoprotein Metabolic Process Collateral Sprouting In Absence Of Injury Protein Metabolic Process Positive Regulation Of Fibrinolysis Blood Coagulation, Extrinsic Pathway Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Plasminogen Activation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Lipid Metabolic Process Neuron Remodeling Response To Stress Protein Autoprocessing Plasma Kallikrein-kinin Cascade Attachment Of GPI Anchor To Protein Regulation Of Fibrinolysis Regulation Of Metabolic Process Blood Coagulation, Intrinsic Pathway Response To Misfolded Protein Cellular Copper Ion Homeostasis Positive Regulation Of Protein Processing
Tagcloud ?		2h behind carbethoxyamino carbodithioate chromen constitutive coumarin cpp cxcl12 derivatives docked docking evidently fifth great hcc hepatocellular invasion methylpyrrolidine oxo p50 p65 reporting scoring suppress survivin tumorigenesis worldwide yl