E2F5

Description		E2F transcription factor 5
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GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Animal Organ Morphogenesis Cell Projection Organization Positive Regulation Of DNA-templated Transcription
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry
Drugs
Diseases
GWAS		Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457)
Novel Interacting Genes		1 novel interacting genes: NSD3
Interacting Genes		8 interacting genes: CREBBP DNMT3L EP300 RBL1 RBL2 SMAD3 TFDP1 XPO1
Entrez ID		1875
HPRD ID		02983
Ensembl ID		ENSG00000133740
Uniprot IDs		Q15329
PDB IDs		5TUV
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex DNA-binding Transcription Factor Binding Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone H3K27 Acetyltransferase Activity Regulation Of RNA Metabolic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Regulation Of Lipid Kinase Activity Transcription Coactivator Binding Promoter-specific Chromatin Binding Regulation Of Gene Expression Chromatin DNA Binding Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process N-terminal Protein Amino Acid Acetylation Positive Regulation Of Protein Localization To Nucleus Peptidyl-lysine Acetylation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Cellular Response To Heat Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Acetyltransferase Activity Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Intracellular Protein Transport Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Localization To Nucleus Regulation Of G1/S Transition Of Mitotic Cell Cycle Histone Acetyltransferase Complex Regulation Of Metabolic Process Protein-lysine-acetyltransferase Activity Negative Regulation Of Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition RNA Polymerase II-specific DNA-binding Transcription Factor Binding
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